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Stfa3 stefin A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288075, updated on 29-Feb-2024

Summary

Official Symbol
Stfa3provided by RGD
Official Full Name
stefin A3provided by RGD
Primary source
RGD:1307831
See related
Ensembl:ENSRNOG00000033933 AllianceGenome:RGD:1307831
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Csta
Summary
Predicted to be involved in negative regulation of endopeptidase activity. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 379.3) See more
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Genomic context

Location:
11q22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77859070..77864212)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64353722..64358864)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67309046..67314181)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene CD86 molecule Neighboring gene uncharacterized LOC134481008 Neighboring gene calcium-sensing receptor Neighboring gene U6 spliceosomal RNA Neighboring gene cystatin A family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General protein information

Preferred Names
cystatin-A
Names
cystatin-alpha
epidermal stefin
epidermal thiol proteinase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105877.1NP_001099347.1  cystatin-A

    See identical proteins and their annotated locations for NP_001099347.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473967
    UniProtKB/Swiss-Prot
    P01039
    UniProtKB/TrEMBL
    A6IRD0
    Related
    ENSRNOP00000043059.3, ENSRNOT00000051936.5
    Conserved Domains (1) summary
    pfam00031
    Location:1097
    Cystatin; Cystatin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    77859070..77864212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)