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Mcoln1 mucolipin TRP cation channel 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288371, updated on 2-May-2024

Summary

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Official Symbol
Mcoln1provided by RGD
Official Full Name
mucolipin TRP cation channel 1provided by RGD
Primary source
RGD:1308953
See related
Ensembl:ENSRNOG00000000975 AllianceGenome:RGD:1308953
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables NAADP-sensitive calcium-release channel activity. Involved in release of sequestered calcium ion into cytosol. Located in lysosomal membrane. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis type IV. Orthologous to human MCOLN1 (mucolipin TRP cation channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 197.5), Brain (RPKM 83.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcoln1 in Genome Data Viewer
Location:
12p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6357851..6372151)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1560341..1574252)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2054629..2068682)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358 Neighboring gene uncharacterized LOC120095868 Neighboring gene patatin-like phospholipase domain containing 6 Neighboring gene calmodulin regulated spectrin-associated protein family, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transient Receptor Potential Mucolipin-1 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing Neuroinflammation and Neuronal Cell Death. Shi J, et al. Neuromolecular Med, 2023 Jun. PMID 36737508
  2. Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver lysosomes of rats. Zhang F, et al. J Biol Chem, 2007 Aug 31. PMID 17613490
  3. The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity. Zhang J, et al. Ecotoxicol Environ Saf, 2023 Jan 15. PMID 36608573
  4. Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning. Tedeschi V, et al. FASEB J, 2021 Feb. PMID 33484198
  5. Human TRPML1 channel structures in open and closed conformations. Schmiege P, et al. Nature, 2017 Oct 19. PMID 29019983, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transient Receptor Potential Mucolipin-1 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing Neuroinflammation and Neuronal Cell Death.
    Title: Transient Receptor Potential Mucolipin-1 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing Neuroinflammation and Neuronal Cell Death.
  2. The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.
    Title: The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.
  3. Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning.
    Title: Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAADP-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAADP-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables iron ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables ligand-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion export ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to pH ISO
Inferred from Sequence Orthology
more info
  
involved_in iron ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mucolipin-1
Names
mucolipin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105903.1 → NP_001099373.1  mucolipin-1

    See identical proteins and their annotated locations for NP_001099373.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474084
    UniProtKB/TrEMBL
    A0A8I6AQ69, A6KQ06
    Related
    ENSRNOP00000096156.1, ENSRNOT00000095810.1
    Conserved Domains (1) summary
    pfam08016
    Location:388 → 524
    PKD_channel; Polycystin cation channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    6357851..6372151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271109.1 → XP_063127179.1  mucolipin-1 isoform X8

  2. XM_063271108.1 → XP_063127178.1  mucolipin-1 isoform X5

  3. XM_039089143.2 → XP_038945071.1  mucolipin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AQ69, A0A8I6G3L4
    Conserved Domains (2) summary
    PLN03223
    Location:388 → 496
    PLN03223; Polycystin cation channel protein; Provisional
    cl41763
    Location:127 → 274
    ELD_TRPML; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)

  4. XM_006248754.5 → XP_006248816.1  mucolipin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ69, A0A8I6G3L4
    Conserved Domains (1) summary
    PLN03223
    Location:457 → 565
    PLN03223; Polycystin cation channel protein; Provisional

  5. XM_006248755.5 → XP_006248817.1  mucolipin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ69, D3ZRF9
    Related
    ENSRNOP00000001290.5
    Conserved Domains (1) summary
    PLN03223
    Location:442 → 550
    PLN03223; Polycystin cation channel protein; Provisional

  6. XM_006248756.5 → XP_006248818.1  mucolipin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AQ69, A0A8I6G3L4
    Conserved Domains (1) summary
    pfam08016
    Location:403 → 539
    PKD_channel; Polycystin cation channel

  7. XM_039089145.2 → XP_038945073.1  mucolipin-1 isoform X7

    Conserved Domains (2) summary
    PLN03223
    Location:148 → 256
    PLN03223; Polycystin cation channel protein; Provisional
    cl41763
    Location:3 → 34
    ELD_TRPML; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)

  8. XM_039089144.2 → XP_038945072.1  mucolipin-1 isoform X6

    Conserved Domains (2) summary
    PLN03223
    Location:217 → 325
    PLN03223; Polycystin cation channel protein; Provisional
    cl41763
    Location:3 → 67
    ELD_TRPML; extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs)

RNA

  1. XR_010056365.1 RNA Sequence

  2. XR_005491602.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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