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Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300862, updated on 13-Apr-2024

Summary

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Official Symbol
Irak1bp1provided by RGD
Official Full Name
interleukin-1 receptor-associated kinase 1 binding protein 1provided by RGD
Primary source
RGD:1305012
See related
Ensembl:ENSRNOG00000008984 AllianceGenome:RGD:1305012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytoplasm and nucleus. Orthologous to human IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 97.0), Testes (RPKM 82.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (92608468..92628377)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (83731512..83748289)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (90343307..90360085)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 4 Neighboring gene pleckstrin homology domain interacting protein Neighboring gene uncharacterized LOC108351752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. Vig E, et al. J Biol Chem, 2001 Mar 16. PMID 11096118
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-1 receptor-associated kinase 1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277283.1 → NP_001264212.1  interleukin-1 receptor-associated kinase 1-binding protein 1

    See identical proteins and their annotated locations for NP_001264212.1

    Status: VALIDATED

    Source sequence(s)
    BC159433, JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I1P8, B0K033, D3ZBV8
    Related
    ENSRNOP00000062372.2, ENSRNOT00000068482.4
    Conserved Domains (1) summary
    pfam04402
    Location:55 → 196
    SIMPL; Protein of unknown function (DUF541)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    92608468..92628377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265187.1 → XP_063121257.1  interleukin-1 receptor-associated kinase 1-binding protein 1 isoform X1

RNA

  1. XR_010053950.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106843.1: Suppressed sequence

    Description
    NM_001106843.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous