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Mbnl3 muscleblind-like splicing regulator 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302492, updated on 11-Apr-2024

Summary

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Official Symbol
Mbnl3provided by RGD
Official Full Name
muscleblind-like splicing regulator 3provided by RGD
Primary source
RGD:1565834
See related
Ensembl:ENSRNOG00000002487 AllianceGenome:RGD:1565834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565834
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within negative regulation of myoblast differentiation. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human MBNL3 (muscleblind like splicing regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 138.1), Thymus (RPKM 77.0) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (135526256..135621499, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (130641942..130737179, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (138378674..138473365, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit gamma, pseudogene 2 Neighboring gene RAP2C, member of RAS oncogene family Neighboring gene small nucleolar RNA SNORA48 Neighboring gene high mobility group protein B4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR. Squillace RM, et al. Dev Biol, 2002 Oct 1. PMID 12297108
  2. Muscleblind proteins regulate alternative splicing. Ho TH, et al. EMBO J, 2004 Aug 4. PMID 15257297, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
muscleblind-like protein 3
Names
muscleblind-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106949.1 → NP_001100419.1  muscleblind-like protein 3

    See identical proteins and their annotated locations for NP_001100419.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473991
    UniProtKB/TrEMBL
    A6JMT4, D3ZQV3
    Related
    ENSRNOP00000039018.3, ENSRNOT00000043258.4
    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    135526256..135621499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279911.1 → XP_063135981.1  muscleblind-like protein 3 isoform X18

  2. XM_063279910.1 → XP_063135980.1  muscleblind-like protein 3 isoform X17

  3. XM_063279909.1 → XP_063135979.1  muscleblind-like protein 3 isoform X16

  4. XM_063279908.1 → XP_063135978.1  muscleblind-like protein 3 isoform X15

  5. XM_039099616.2 → XP_038955544.1  muscleblind-like protein 3 isoform X12

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  6. XM_063279907.1 → XP_063135977.1  muscleblind-like protein 3 isoform X11

  7. XM_063279906.1 → XP_063135976.1  muscleblind-like protein 3 isoform X9

  8. XM_039099609.2 → XP_038955537.1  muscleblind-like protein 3 isoform X3

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  9. XM_039099613.2 → XP_038955541.1  muscleblind-like protein 3 isoform X7

    UniProtKB/TrEMBL
    A6JMT4, D3ZQV3
    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  10. XM_039099611.2 → XP_038955539.1  muscleblind-like protein 3 isoform X5

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  11. XM_039099620.2 → XP_038955548.1  muscleblind-like protein 3 isoform X14

    UniProtKB/TrEMBL
    A0A8I6GLQ8
    Conserved Domains (1) summary
    smart00356
    Location:80 → 104
    ZnF_C3H1; zinc finger

  12. XM_039099622.2 → XP_038955550.1  muscleblind-like protein 3 isoform X13

    UniProtKB/TrEMBL
    A0A8I6GLQ8
    Related
    ENSRNOP00000095651.1
    Conserved Domains (1) summary
    smart00356
    Location:80 → 104
    ZnF_C3H1; zinc finger

  13. XM_039099615.2 → XP_038955543.1  muscleblind-like protein 3 isoform X10

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  14. XM_039099614.2 → XP_038955542.1  muscleblind-like protein 3 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZQQ7
    Related
    ENSRNOP00000080997.1
    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  15. XM_039099612.2 → XP_038955540.1  muscleblind-like protein 3 isoform X6

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  16. XM_039099610.2 → XP_038955538.1  muscleblind-like protein 3 isoform X4

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  17. XM_039099608.2 → XP_038955536.1  muscleblind-like protein 3 isoform X2

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  18. XM_039099606.2 → XP_038955534.1  muscleblind-like protein 3 isoform X1

    Conserved Domains (1) summary
    smart00356
    Location:176 → 200
    ZnF_C3H1; zinc finger

  19. XM_039099617.2 → XP_038955545.1  muscleblind-like protein 3 isoform X13

    UniProtKB/TrEMBL
    A0A8I6GLQ8
    Conserved Domains (1) summary
    smart00356
    Location:80 → 104
    ZnF_C3H1; zinc finger

  20. XM_039099618.2 → XP_038955546.1  muscleblind-like protein 3 isoform X13

    UniProtKB/TrEMBL
    A0A8I6GLQ8
    Conserved Domains (1) summary
    smart00356
    Location:80 → 104
    ZnF_C3H1; zinc finger
Nucleotide Protein Strain
Heading Accession and Version

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