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Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304193, updated on 6-Jun-2024

Summary

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Official Symbol
Arhgef18provided by RGD
Official Full Name
Rho/Rac guanine nucleotide exchange factor 18provided by RGD
Primary source
RGD:1311448
See related
Ensembl:ENSRNOG00000028090 AllianceGenome:RGD:1311448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly and protein localization to cell-cell junction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 116.6), Kidney (RPKM 91.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef18 in Genome Data Viewer
Location:
12p12
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6192958..6300997)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1395035..1503082)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1889252..1998128)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene insulin receptor Neighboring gene uncharacterized LOC134481143 Neighboring gene uncharacterized LOC134481144 Neighboring gene uncharacterized LOC120095867 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. Niu J, et al. Circ Res, 2003 Oct 31. PMID 14512443
  2. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
  3. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation. Tornavaca O, et al. J Cell Biol, 2015 Mar 16. PMID 25753039, Free PMC Article
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 18
Names
rho/rac guanine nucleotide exchange factor (GEF) 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395655.2 → NP_001382584.2  rho guanine nucleotide exchange factor 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5ZLL3
    Related
    ENSRNOP00000078753.1, ENSRNOT00000110862.1

  2. NM_001429753.1 → NP_001416682.1  rho guanine nucleotide exchange factor 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5ZLL3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    6192958..6300997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271243.1 → XP_063127313.1  rho guanine nucleotide exchange factor 18 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLL3

  2. XM_063271244.1 → XP_063127314.1  rho guanine nucleotide exchange factor 18 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLL3

  3. XM_063271245.1 → XP_063127315.1  rho guanine nucleotide exchange factor 18 isoform X3

  4. XM_039089307.2 → XP_038945235.1  rho guanine nucleotide exchange factor 18 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLL3
    Conserved Domains (4) summary
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:336 → 454
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:661 → 784
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:741 → 956
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107115.1: Suppressed sequence

    Description
    NM_001107115.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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