Znf846 zinc finger protein 846 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Znf846provided by RGD
Official Full Name: zinc finger protein 846provided by RGD
Primary source: RGD:1566386
See related: Ensembl:ENSRNOG00000028651 AllianceGenome:RGD:1566386
Gene type: protein coding
RefSeq status: PREDICTED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566386
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZNF487 (zinc finger protein 487). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 54.7), Kidney (RPKM 47.3) and 9 other tissues See more
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Genomic context

Location:: 12q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (21093096..21126705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15979312..16012933, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (18105821..18139420, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein LOC304336

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107127.2 → NP_001100597.2 uncharacterized protein LOC304336

See identical proteins and their annotated locations for NP_001100597.2

Status: PREDICTED

Source sequence(s)

BC167756

UniProtKB/TrEMBL

B3DM98

Conserved Domains (6) summary

smart00349
Location:13 → 72

KRAB; krueppel associated box

COG5048
Location:395 → 663

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:506 → 526

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:644 → 666

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:13 → 52

KRAB; KRAB box

pfam13465
Location:574 → 599

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

21093096..21126705 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089397.2 → XP_038945325.1 uncharacterized protein LOC304336 isoform X1

Conserved Domains (3) summary

smart00349
Location:43 → 102

KRAB; krueppel associated box

COG5048
Location:425 → 697

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:536 → 556

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_039089398.2 → XP_038945326.1 uncharacterized protein LOC304336 isoform X2

UniProtKB/TrEMBL

E9PU41

Related

ENSRNOP00000038237.6

Conserved Domains (3) summary

smart00349
Location:4 → 63

KRAB; krueppel associated box

COG5048
Location:386 → 658

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:497 → 517

ZF_C2H2; C2H2 Zn finger [structural motif]