serpinh1b serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: serpinh1bprovided by ZNC
Official Full Name: serpin peptidase inhibitor, clade H (heat shock protein 47), member 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-93
See related: Ensembl:ENSDARG00000019949 AllianceGenome:ZFIN:ZDB-GENE-990415-93
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsp; cb216; hsp47; fc56b02; id:ibd5060; wu:fc56b02
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within fin regeneration. Predicted to be located in extracellular space. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including ectoderm; fin; germ ring; mesenchyme derived from head mesoderm; and mesoderm. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 10 and preterm premature rupture of the membranes. Orthologous to human SERPINH1 (serpin family H member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (29383204..29387466, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (29450326..29454705, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone responsible for proper folding of procollagen molecules.
Title: Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin.

Submit: New GeneRIF Correction

General gene information

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Markers

hsp47 (e-PCR), detects polymorphism
- UniSTS:205601

HSP47 (e-PCR)
- UniSTS:205388

hsp47 (e-PCR), detects polymorphism
- UniSTS:204644

fc56b02 (e-PCR)
- UniSTS:189378

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serpin H1b

Names: heat shock protein 47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309823.1 → NP_001296752.1 serpin H1b precursor

See identical proteins and their annotated locations for NP_001296752.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BX537138

UniProtKB/TrEMBL

A0A8M1P290, F1QQ04, F1R7F7

Related

ENSDARP00000097918.2, ENSDART00000115032.2

Conserved Domains (1) summary

cd02046
Location:28 → 393

hsp47; Heat shock protein 47 (Hsp47), also called colligin, because of its collagen binding ability, is a chaperone specific for procollagen. It has been shown to be essential for collagen biosynthesis, but its exact function is still unclear. Hsp47 is a ...
NM_131204.2 → NP_571279.2 serpin H1b precursor

See identical proteins and their annotated locations for NP_571279.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BX537138

UniProtKB/TrEMBL

A0A8M1P290, F1QQ04, F1R7F7

Related

ENSDARP00000037780.4, ENSDART00000035096.6

Conserved Domains (1) summary

cd02046
Location:28 → 393

hsp47; Heat shock protein 47 (Hsp47), also called colligin, because of its collagen binding ability, is a chaperone specific for procollagen. It has been shown to be essential for collagen biosynthesis, but its exact function is still unclear. Hsp47 is a ...