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sox17 - SRY-box transcription factor 17

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within Kupffer's vesicle development; determination of left/right symmetry; and primitive hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including Kupffer's vesicle; endoderm; lateral plate mesoderm; liver and biliary system; and presumptive structure. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human SOX17 (SRY-box transcription factor 17). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa