aanat2 arylalkylamine N-acetyltransferase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aanat2provided by ZNC
Official Full Name: arylalkylamine N-acetyltransferase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-991019-6
See related: Ensembl:ENSDARG00000079802 AllianceGenome:ZFIN:ZDB-GENE-991019-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: AA-NAT
Summary: Enables acetyltransferase activity. Acts upstream of or within several processes, including neutrophil chemotaxis; photoperiodism; and positive regulation of circadian sleep/wake cycle, sleep. Predicted to be active in cytoplasm. Is expressed in brain; ovary; and retina. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (54887825..54893706)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (54633223..54639104)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that CK1delta inhibition abolishes rhythmic pineal aanat2 mRNA expression.
Title: Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.
rhythmicity of AANAT2 can be initiated by a pulse of light against a background of constant darkness, by a pulse of darkness against a background of constant lighting, or by single light-to-dark or dark-to-light transitions
Title: Starting the zebrafish pineal circadian clock with a single photic transition.
In constant darkness, the rhythmic expression of retinal aanat2 persisted while the aanat1 rhythm disappeared
Title: Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables aralkylamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aralkylamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoperiodism	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to light stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to light stimulus	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: arylalkylamine N-acetyltransferase 2

Names: serotonin N-acetyltransferase-2

NP_571486.1

EC 2.3.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131411.3 → NP_571486.1 arylalkylamine N-acetyltransferase 2

See identical proteins and their annotated locations for NP_571486.1

Status: VALIDATED

Source sequence(s)

CT573860

UniProtKB/TrEMBL

A0A8M1PC12, Q9PVD7

Related

ENSDARP00000002650.7, ENSDART00000018205.8

Conserved Domains (2) summary

COG0456
Location:35 → 179

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:87 → 176

Acetyltransf_1; Acetyltransferase (GNAT) family