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notch1a - notch receptor 1a

Predicted to enable Notch binding activity. Involved in Notch signaling pathway and hematopoietic stem cell differentiation. Acts upstream of or within with a positive effect on NIK/NF-kappaB signaling. Acts upstream of or within several processes, including animal organ development; neurogenesis; and regulation of cell fate specification. Is active in plasma membrane. Is expressed in several structures, including digestive system; fin; mesoderm; nervous system; and tail bud. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

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Species Gene Architecture aa