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Adnp2 ADNP homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307236, updated on 3-Apr-2024

Summary

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Official Symbol
Adnp2provided by RGD
Official Full Name
ADNP homeobox 2provided by RGD
Primary source
RGD:1308279
See related
Ensembl:ENSRNOG00000053370 AllianceGenome:RGD:1308279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308279
Summary
Predicted to enable DNA binding activity. Predicted to be involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Orthologous to human ADNP2 (ADNP homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 68.2), Lung (RPKM 62.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adnp2 in Genome Data Viewer
Location:
18q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (75846860..75871638, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73571870..73597088, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76637415..76661186, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1, pseudogene 5 Neighboring gene par-6 family cell polarity regulator gamma Neighboring gene uncharacterized LOC120098235 Neighboring gene uncharacterized LOC134483064 Neighboring gene uncharacterized LOC108348824 Neighboring gene 60S acidic ribosomal protein P0 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress. Kushnir M, et al. J Neurochem, 2008 Apr. PMID 18179478
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188386

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
activity-dependent neuroprotector homeobox protein 2
Names
ADNP homeobox protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127373.1 → NP_001120845.1  activity-dependent neuroprotector homeobox protein 2

    See identical proteins and their annotated locations for NP_001120845.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166606
    UniProtKB/TrEMBL
    A0A8I6A6N1, B2GVB8
    Conserved Domains (2) summary
    smart00389
    Location:1045 → 1098
    HOX; Homeodomain
    pfam15757
    Location:347 → 479
    Amelotin; Amelotin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    75846860..75871638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096772.2 → XP_038952700.1  activity-dependent neuroprotector homeobox protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZJ89, A0A8I6A6N1
    Related
    ENSRNOP00000076656.1
    Conserved Domains (2) summary
    smart00389
    Location:1103 → 1156
    HOX; Homeodomain
    PHA03247
    Location:334 → 797
    PHA03247; large tegument protein UL36; Provisional

  2. XM_063277295.1 → XP_063133365.1  activity-dependent neuroprotector homeobox protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AMU3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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