melk maternal embryonic leucine zipper kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: melkprovided by ZNC
Official Full Name: maternal embryonic leucine zipper kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990603-5
See related: Ensembl:ENSDARG00000030759 AllianceGenome:ZFIN:ZDB-GENE-990603-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb71b01; fe01f04; wu:fb71b01; wu:fe01f04
Summary: Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in hemopoiesis. Acts upstream of or within erythrocyte development and regulation of heart contraction. Predicted to be located in cell cortex. Is expressed in several structures, including digestive system; immature eye; nervous system; pleuroperitoneal region; and proliferative region. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (21861387..21881818, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (21168450..21188881, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melk-like gene may play a role in primitive hematopoiesis by affecting the expression of genes critical for hematopoiesis.
Title: Melk-like kinase plays a role in hematopoiesis in the zebra fish.

Submit: New GeneRIF Correction

General gene information

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Markers

fk58b12.x1 (e-PCR)
- UniSTS:201241

MELK (e-PCR)
- UniSTS:205372

fb71b01.x1 (e-PCR)
- UniSTS:191044

fe01f04.x1 (e-PCR)
- UniSTS:195915

STS75.B9 (e-PCR)
- UniSTS:205698

fb71b01 (e-PCR)
- UniSTS:187379

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: maternal embryonic leucine zipper kinase

Names: protein kinase PK38; zMelk

NP_996771.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_206888.2 → NP_996771.2 maternal embryonic leucine zipper kinase

See identical proteins and their annotated locations for NP_996771.2

Status: PROVISIONAL

Source sequence(s)

BC050520

UniProtKB/Swiss-Prot

F1QGZ6, Q7ZU72, Q7ZZN5

Related

ENSDARP00000047727.6, ENSDART00000047728.7

Conserved Domains (4) summary

cd12198
Location:577 → 671

MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase

smart00220
Location:13 → 264

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14341
Location:283 → 334

UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins

cd14078
Location:9 → 264

STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase