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Rbmxl1 Rbmx like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307779, updated on 11-Apr-2024

Summary

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Official Symbol
Rbmxl1provided by RGD
Official Full Name
Rbmx like 1provided by RGD
Primary source
RGD:1306751
See related
Ensembl:ENSRNOG00000062375 AllianceGenome:RGD:1306751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rbmx; Rbmxrt; Rbmxrtl
Summary
Enables RNA binding activity. Involved in protein-containing complex assembly and regulation of mRNA splicing, via spliceosome. Part of supraspliceosomal complex. Orthologous to human RBMXL1 (RBMX like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 228.6), Spleen (RPKM 183.6) and 9 other tissues See more
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Genomic context

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Location:
19q11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (46312176..46315802)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (29407902..29411519)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (33081473..33084988)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene reeler domain containing 1 Neighboring gene solute carrier family 10, member 7 Neighboring gene large ribosomal subunit protein eL28-like Neighboring gene 60S ribosomal protein L21-like Neighboring gene POU class 4 homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. Takemoto T, et al. FEBS Lett, 2007 Jan 23. PMID 17188681
  2. SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. Omura Y, et al. BMB Rep, 2009 Apr 30. PMID 19403048
  3. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. Heinrich B, et al. J Biol Chem, 2009 May 22. PMID 19282290, Free PMC Article
  4. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. Wang J, et al. J Neurochem, 2004 Mar. PMID 15009664
  5. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Misawa K, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10716735, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of euchromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of supraspliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding motif protein, X chromosome retrogene-like
Names
RNA binding motif protein, X chromosome retrogene
RNA binding motif protein, X chromosome retrogene-like
RNA binding motif protein, X-linked-like 1
heterogeneous nuclear ribonucleoprotein G retrogene-like
hnRNP G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107420.1 → NP_001100890.1  RNA-binding motif protein, X chromosome retrogene-like

    See identical proteins and their annotated locations for NP_001100890.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/Swiss-Prot
    P84586
    UniProtKB/TrEMBL
    A0A8I6AKQ4, A6IYJ5
    Conserved Domains (3) summary
    COG0724
    Location:1 → 85
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:170 → 214
    RBM1CTR; RBM1CTR (NUC064) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    46312176..46315802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097729.2 → XP_038953657.1  RNA-binding motif protein, X chromosome retrogene-like isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN66, A0A8I6AKQ4
    Related
    ENSRNOP00000079505.1
    Conserved Domains (3) summary
    PRK14086
    Location:162 → 303
    dnaA; chromosomal replication initiator protein DnaA
    pfam08081
    Location:170 → 214
    RBM1CTR; RBM1CTR (NUC064) family
    cd12382
    Location:7 → 86
    RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

  2. XM_063278022.1 → XP_063134092.1  RNA-binding motif protein, X chromosome retrogene-like isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84586.1 GenPept UniProtKB/Swiss-Prot:P84586

Gene LinkOut

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