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Hddc3 HD domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308758, updated on 5-Mar-2024

Summary

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Official Symbol
Hddc3provided by RGD
Official Full Name
HD domain containing 3provided by RGD
Primary source
RGD:1311839
See related
Ensembl:ENSRNOG00000012236 AllianceGenome:RGD:1311839
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311839
Summary
Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Orthologous to human HDDC3 (HD domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 168.2), Kidney (RPKM 134.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143708703..143711010)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134299469..134301757)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142136428..142138737)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene shisa like 3 Neighboring gene ribosomal protein L35A like 7 Neighboring gene mannosidase, alpha, class 2A, member 2 Neighboring gene FES proto-oncogene, tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Names
HD domain-containing protein 3
NP_001100998.1
XP_006229493.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107528.1 → NP_001100998.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

    See identical proteins and their annotated locations for NP_001100998.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473980
    UniProtKB/TrEMBL
    A6JCA5, D4A500
    Related
    ENSRNOP00000016445.4, ENSRNOT00000016445.6
    Conserved Domains (1) summary
    COG0317
    Location:4 → 130
    SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    143708703..143711010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229431.3 → XP_006229493.1  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQC5
    Related
    ENSRNOP00000080516.1
    Conserved Domains (2) summary
    COG0317
    Location:4 → 95
    SpoT; (p)ppGpp synthase/hydrolase, HD superfamily [Signal transduction mechanisms, Transcription]
    cl21469
    Location:3 → 103
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
Nucleotide Protein Strain
Heading Accession and Version

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