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Sorcs1 sortilin-related VPS10 domain containing receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309533, updated on 11-Apr-2024

Summary

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Official Symbol
Sorcs1provided by RGD
Official Full Name
sortilin-related VPS10 domain containing receptor 1provided by RGD
Primary source
RGD:1305910
See related
Ensembl:ENSRNOG00000011313 AllianceGenome:RGD:1305910
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Predicted to be integral component of membrane. Used to study proteinuria. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 68.6), Kidney (RPKM 23.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sorcs1 in Genome Data Viewer
Location:
1q55
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (259022007..259535731, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (249080662..249594520, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (269965824..270473097, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554215 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 4 Neighboring gene uncharacterized LOC134485246 Neighboring gene uncharacterized LOC120097667 Neighboring gene uncharacterized LOC102554335 Neighboring gene uncharacterized LOC134485247 Neighboring gene large ribosomal subunit protein eL29-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells. Yau B, et al. Sci Rep, 2019 Dec 19. PMID 31857633, Free PMC Article
  2. SORCS1 contributes to the development of renal disease in rats and humans. Lazar J, et al. Physiol Genomics, 2013 Aug 15. PMID 23780848, Free PMC Article
  3. SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function. Ribeiro LF, et al. PLoS Biol, 2019 Oct. PMID 31658245, Free PMC Article
  4. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. Hermey G, et al. J Biol Chem, 2003 Feb 28. PMID 12482870
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 beta-cells.
    Title: Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells.
  2. SorCS1-mediated sorting in dendritic endosomes controls Nrxn axonal surface polarization required for proper synapse development and function.
    Title: SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
  3. The experimental data from the rat combined with association results from different ethnic groups indicates a role for SORCS1 in maintaining proper renal function.
    Title: SORCS1 contributes to the development of renal disease in rats and humans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
VPS10 domain-containing receptor SorCS1
Names
VPS10 domain receptor protein SORCS 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191563.1 → NP_001178492.1  VPS10 domain-containing receptor SorCS1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1LUZ4
    Related
    ENSRNOP00000015979.3, ENSRNOT00000015979.5
    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    259022007..259535731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231521.5 → XP_006231583.1  VPS10 domain-containing receptor SorCS1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLQ5
    Related
    ENSRNOP00000078816.1
    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

  2. XM_006231519.5 → XP_006231581.1  VPS10 domain-containing receptor SorCS1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEA1
    Related
    ENSRNOP00000090827.1
    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

  3. XM_006231520.5 → XP_006231582.1  VPS10 domain-containing receptor SorCS1 isoform X2

    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

  4. XM_006231525.4 → XP_006231587.1  VPS10 domain-containing receptor SorCS1 isoform X7

    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

  5. XM_039080712.2 → XP_038936640.1  VPS10 domain-containing receptor SorCS1 isoform X6

    Conserved Domains (2) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain

  6. XM_006231523.5 → XP_006231585.1  VPS10 domain-containing receptor SorCS1 isoform X5

    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

  7. XM_063265314.1 → XP_063121384.1  VPS10 domain-containing receptor SorCS1 isoform X11

  8. XM_039080717.2 → XP_038936645.1  VPS10 domain-containing receptor SorCS1 isoform X8

    UniProtKB/TrEMBL
    A6JHS6
    Conserved Domains (2) summary
    smart00602
    Location:20 → 617
    VPS10; VPS10 domain
    pfam00801
    Location:631 → 704
    PKD; PKD domain

  9. XM_039080727.1 → XP_038936655.1  VPS10 domain-containing receptor SorCS1 isoform X10

    Conserved Domains (2) summary
    smart00602
    Location:1 → 316
    VPS10; VPS10 domain
    pfam00801
    Location:330 → 403
    PKD; PKD domain

  10. XM_039080722.2 → XP_038936650.1  VPS10 domain-containing receptor SorCS1 isoform X9

    Conserved Domains (2) summary
    smart00602
    Location:26 → 348
    VPS10; VPS10 domain
    pfam00801
    Location:362 → 435
    PKD; PKD domain

  11. XM_006231522.5 → XP_006231584.1  VPS10 domain-containing receptor SorCS1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AF53
    Related
    ENSRNOP00000091270.1
    Conserved Domains (3) summary
    smart00602
    Location:196 → 793
    VPS10; VPS10 domain
    pfam00801
    Location:807 → 880
    PKD; PKD domain
    pfam15901
    Location:638 → 793
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
Nucleotide Protein Strain
Heading Accession and Version

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