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Cgn cingulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 310655, updated on 6-Jun-2024

Summary

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Official Symbol
Cgnprovided by RGD
Official Full Name
cingulinprovided by RGD
Primary source
RGD:1311992
See related
Ensembl:ENSRNOG00000020952 AllianceGenome:RGD:1311992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microtubule binding activity. Predicted to act upstream of or within bicellular tight junction assembly; epithelial cell morphogenesis; and microtubule cytoskeleton organization. Predicted to be located in bicellular tight junction; brush border; and plasma membrane. Predicted to be part of myosin complex. Orthologous to human CGN (cingulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 100.7), Kidney (RPKM 80.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cgn in Genome Data Viewer
Location:
2q34
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (184997425..185024785, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182308389..182335747, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (195909691..195937130, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding factor 2 like 1 Neighboring gene tuftelin 1 Neighboring gene uncharacterized LOC120100872 Neighboring gene uncharacterized LOC134485648 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5, pseudogene 2 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene high mobility group protein B1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK. Yano T, et al. J Cell Biol, 2013 Nov 25. PMID 24385485, Free PMC Article
  2. JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin. Ohnishi H, et al. J Biol Chem, 2004 Oct 29. PMID 15292197
  3. Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. Guillemot L, et al. J Cell Sci, 2012 Nov 1. PMID 22946046
  4. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
  5. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cingulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427774.1 → NP_001414703.1  cingulin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6A4L9, D4A4X4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    184997425..185024785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232929.4 → XP_006232991.1  cingulin isoform X1

    See identical proteins and their annotated locations for XP_006232991.1

    UniProtKB/TrEMBL
    A0A8I6A4L9, D4A4X4
    Conserved Domains (3) summary
    pfam01576
    Location:362 → 1146
    Myosin_tail_1; Myosin tail
    pfam11262
    Location:1084 → 1165
    Tho2; Transcription factor/nuclear export subunit protein 2
    cl23720
    Location:1017 → 1118
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_006232928.5 → XP_006232990.1  cingulin isoform X1

    See identical proteins and their annotated locations for XP_006232990.1

    UniProtKB/TrEMBL
    A0A8I6A4L9, D4A4X4
    Related
    ENSRNOP00000085785.1
    Conserved Domains (3) summary
    pfam01576
    Location:362 → 1146
    Myosin_tail_1; Myosin tail
    pfam11262
    Location:1084 → 1165
    Tho2; Transcription factor/nuclear export subunit protein 2
    cl23720
    Location:1017 → 1118
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_063281870.1 → XP_063137940.1  cingulin isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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