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Sass6 SAS-6 centriolar assembly protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 310807, updated on 13-Apr-2024

Summary

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Symbol
Sass6provided by RGD
Full Name
SAS-6 centriolar assembly proteinprovided by RGD
Primary source
RGD:1306255
See related
Ensembl:ENSRNOG00000015211 AllianceGenome:RGD:1306255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306255
Summary
Predicted to be involved in centriole replication. Predicted to be located in cytosol; deuterosome; and microtubule organizing center. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 81.9), Spleen (RPKM 51.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q42
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207231896..207263840)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204546660..204578930)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219626851..219660975)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene dihydrolipoamide branched chain transacylase E2 Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene uncharacterized LOC102548510 Neighboring gene solute carrier family 35 member A3 Neighboring gene amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nucleoporin Nup62 maintains centrosome homeostasis. Hashizume C, et al. Cell Cycle, 2013 Dec 15. PMID 24107630, Free PMC Article
  2. The Polo kinase Plk4 functions in centriole duplication. Habedanck R, et al. Nat Cell Biol, 2005 Nov. PMID 16244668
  3. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Leidel S, et al. Nat Cell Biol, 2005 Feb. PMID 15665853
  4. Deuterosome-mediated centriole biogenesis. Klos Dehring DA, et al. Dev Cell, 2013 Oct 14. PMID 24075808, Free PMC Article
  5. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. Tang CJ, et al. EMBO J, 2011 Oct 21. PMID 22020124, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in deuterosome ISO
Inferred from Sequence Orthology
more info
  
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spindle assembly abnormal protein 6 homolog
Names
spindle assembly 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415058.1 → NP_001401987.1  spindle assembly abnormal protein 6 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GMD5, A6HVA1
    Related
    ENSRNOP00000097084.1, ENSRNOT00000112539.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    207231896..207263840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281937.1 → XP_063138007.1  spindle assembly abnormal protein 6 homolog isoform X1

  2. XM_063281938.1 → XP_063138008.1  spindle assembly abnormal protein 6 homolog isoform X2

    UniProtKB/TrEMBL
    D3ZVI7

  3. XM_006233228.4 → XP_006233290.1  spindle assembly abnormal protein 6 homolog isoform X3

    UniProtKB/TrEMBL
    A6HVA3
    Related
    ENSRNOP00000063437.3
    Conserved Domains (3) summary
    cd00187
    Location:360 → 480
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    pfam16531
    Location:46 → 140
    SAS-6_N; Centriolar protein SAS N-terminal
    cl21455
    Location:56 → 348
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_063281939.1 → XP_063138009.1  spindle assembly abnormal protein 6 homolog isoform X4

  5. XM_039102429.2 → XP_038958357.1  spindle assembly abnormal protein 6 homolog isoform X5

    UniProtKB/TrEMBL
    A6HVA2
    Conserved Domains (2) summary
    TIGR02168
    Location:165 → 464
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd10142
    Location:4 → 144
    HD_SAS6_N; N-terminal head domain found in spindle assembly abnormal protein 6 and similar proteins

  6. XM_063281940.1 → XP_063138010.1  spindle assembly abnormal protein 6 homolog isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107719.1: Suppressed sequence

    Description
    NM_001107719.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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