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Invs inversin [ Rattus norvegicus (Norway rat) ]

Gene ID: 313228, updated on 11-Apr-2024

Summary

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Official Symbol
Invsprovided by RGD
Official Full Name
inversinprovided by RGD
Primary source
RGD:1563359
See related
Ensembl:ENSRNOG00000008632 AllianceGenome:RGD:1563359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563359
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and protein localization to ciliary inversin compartment. Predicted to act upstream of or within several processes, including animal organ development; epithelial cilium movement involved in determination of left/right asymmetry; and protein phosphorylation. Predicted to be located in ciliary base. Predicted to be active in ciliary inversin compartment. Human ortholog(s) of this gene implicated in nephronophthisis 2. Orthologous to human INVS (inversin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 39.4), Lung (RPKM 31.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (67406511..67559355)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (62610916..62763813)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64031131..64180830)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene syntaxin 17 Neighboring gene exosome component 8, pseudogene 1 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene uncharacterized LOC102551711 Neighboring gene testis expressed 10 Neighboring gene uncharacterized LOC108350968 Neighboring gene Myb/SANT DNA binding domain containing 3 Neighboring gene transmembrane protein with EGF-like and two follistatin-like domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules. Li L, et al. Endocrinology, 2022 Apr 1. PMID 35106541, Free PMC Article
  2. Multiple renal cyst development but not situs abnormalities in transgenic RNAi mice against Inv::GFP rescue gene. Kamijho Y, et al. PLoS One, 2014. PMID 24586938, Free PMC Article
  3. Sustained cell proliferation of renal epithelial cells in mice with inv mutation. Sugiyama N, et al. Genes Cells, 2006 Oct. PMID 16999740
  4. Anomalous development of the hepatobiliary system in the Inv mouse. Mazziotti MV, et al. Hepatology, 1999 Aug. PMID 10421642
  5. Mutations of NPHP2 and NPHP3 in infantile nephronophthisis. Tory K, et al. Kidney Int, 2009 Apr. PMID 19177160

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules.
    Title: PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within animal organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic heart tube left/right pattern formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pancreas development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to ciliary inversin compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to ciliary inversin compartment ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary inversin compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary inversin compartment ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inversin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107932.2 → NP_001101402.1  inversin

    See identical proteins and their annotated locations for NP_001101402.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6KJF5, D4A4A8
    Related
    ENSRNOP00000011622.8, ENSRNOT00000011622.8
    Conserved Domains (4) summary
    cd00204
    Location:384 → 509
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:427 → 517
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:356 → 387
    ANK; ANK repeat [structural motif]
    cl00936
    Location:628 → 816
    RecX; RecX family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    67406511..67559355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109855.2 → XP_038965783.1  inversin isoform X1

    Conserved Domains (6) summary
    PHA02874
    Location:62 → 262
    PHA02874; ankyrin repeat protein; Provisional
    PHA03307
    Location:634 → 899
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0666
    Location:252 → 400
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:378 → 409
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:33 → 88
    Ank_5; Ankyrin repeats (many copies)
    cl39094
    Location:358 → 576
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039109856.2 → XP_038965784.1  inversin isoform X2

    Conserved Domains (6) summary
    PHA02874
    Location:62 → 262
    PHA02874; ankyrin repeat protein; Provisional
    COG0666
    Location:252 → 400
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:378 → 409
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:33 → 88
    Ank_5; Ankyrin repeats (many copies)
    NF033838
    Location:617 → 710
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:358 → 576
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_039109857.2 → XP_038965785.1  inversin isoform X3

    Conserved Domains (6) summary
    PHA02874
    Location:62 → 262
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:356 → 387
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:225 → 311
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:33 → 88
    Ank_5; Ankyrin repeats (many copies)
    NF033838
    Location:595 → 688
    PspC_subgroup_1; pneumococcal surface protein PspC, choline-binding form
    cl39094
    Location:336 → 554
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039109860.2 → XP_038965788.1  inversin isoform X4

    Conserved Domains (5) summary
    PHA02874
    Location:62 → 262
    PHA02874; ankyrin repeat protein; Provisional
    COG0666
    Location:252 → 400
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:378 → 409
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:33 → 88
    Ank_5; Ankyrin repeats (many copies)
    cl39094
    Location:358 → 576
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_039109859.2 → XP_038965787.1  inversin isoform X4

    Conserved Domains (5) summary
    PHA02874
    Location:62 → 262
    PHA02874; ankyrin repeat protein; Provisional
    COG0666
    Location:252 → 400
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:378 → 409
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:33 → 88
    Ank_5; Ankyrin repeats (many copies)
    cl39094
    Location:358 → 576
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_063287624.1 → XP_063143694.1  inversin isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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