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Togaram1 TOG array regulator of axonemal microtubules 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314169, updated on 13-Apr-2024

Summary

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Official Symbol
Togaram1provided by RGD
Official Full Name
TOG array regulator of axonemal microtubules 1provided by RGD
Primary source
RGD:1310474
See related
Ensembl:ENSRNOG00000004415 AllianceGenome:RGD:1310474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam179b; RGD1310474
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle assembly and positive regulation of microtubule polymerization. Predicted to be located in ciliary basal body. Predicted to be active in cilium and microtubule cytoskeleton. Predicted to colocalize with microtubule. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human TOGARAM1 (TOG array regulator of axonemal microtubules 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 113.0), Lung (RPKM 112.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Togaram1 in Genome Data Viewer
Location:
6q24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (88755264..88819599)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (83019025..83083343)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (86713588..86780134)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 14 open reading frame 28 Neighboring gene kelch-like family member 28 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127 Neighboring gene FKBP prolyl isomerase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Das A, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378256, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TOG array regulator of axonemal microtubules protein 1
Names
family with sequence similarity 179, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427294.1 → NP_001414223.1  TOG array regulator of axonemal microtubules protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    D4ABJ6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    88755264..88819599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_234236.11 → XP_234236.4  TOG array regulator of axonemal microtubules protein 1 isoform X1

    See identical proteins and their annotated locations for XP_234236.4

    UniProtKB/TrEMBL
    D3ZW60
    Related
    ENSRNOP00000056038.2
    Conserved Domains (2) summary
    pfam15402
    Location:789 → 905
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]

  2. XM_008764689.4 → XP_008762911.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

    See identical proteins and their annotated locations for XP_008762911.1

    Conserved Domains (2) summary
    pfam15402
    Location:789 → 905
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]

  3. XM_006240139.5 → XP_006240201.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006240201.1

    UniProtKB/TrEMBL
    A0A8I6AG72
    Related
    ENSRNOP00000091738.1
    Conserved Domains (2) summary
    pfam15402
    Location:789 → 905
    Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]

  4. XM_063261915.1 → XP_063117985.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

  5. XM_039113217.2 → XP_038969145.1  TOG array regulator of axonemal microtubules protein 1 isoform X5

    Conserved Domains (1) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]

  6. XM_039113218.2 → XP_038969146.1  TOG array regulator of axonemal microtubules protein 1 isoform X7

    Conserved Domains (1) summary
    sd00044
    Location:395 → 419
    HEAT; HEAT repeat [structural motif]

  7. XM_063261916.1 → XP_063117986.1  TOG array regulator of axonemal microtubules protein 1 isoform X6

RNA

  1. XR_010052087.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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