Adamts7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adamts7provided by RGD
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 7provided by RGD
Primary source: RGD:1306713
See related: Ensembl:ENSRNOG00000028036 AllianceGenome:RGD:1306713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: COMPase; ADAM-TS7; ADAMTS-7; ADAMTS7B; ADAM-TS 7
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; collagen fibril organization; and skeletal system development. Predicted to act upstream of or within proteolysis. Predicted to be located in cell surface. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 50.5), Uterus (RPKM 35.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (99584529..99624132)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (90704727..90744333)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (97535777..97575661)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of miR423 improves autologous vein graft restenosis via targeting ADAMTS7.
Title: Upregulation of miR‑423 improves autologous vein graft restenosis via targeting ADAMTS‑7.
In conclusion, the changes in the expression of lncRNAs, mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly affect endometrial receptivity in rats with endometriosis during the implantation window, probably resulting in implantation failure of the embryo.
Title: lncRNA/mRNA profiling of endometriosis rat uterine tissues during the implantation window.
Study shows that elevated ADAMTS-7 levels may be involved in ventricular remodeling after acute myocardial infarction.
Title: Association of ADAMTS-7 Levels with Cardiac Function in a Rat Model of Acute Myocardial Infarction.
data demonstrates that ADAMTS-7 promotes VSMC proliferation both in vitro and in vivo. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and post-angioplasty restenosis
Title: ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo.
ADAMTS-7 and TNF-alpha form a positive feedback loop in the regulation of cartilage degradation and osteoarthritis progression.
Title: ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis.
ADAMTS-7 upregulation by miR-29a/b repression mediates vascular calcification, which may shed light on preventing cardiovascular morbidity and mortality.
Title: Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7 by miR-29 repression mediates vascular smooth muscle calcification.
ADAMTS-7 and ADAMTS-12 expression were dramatically increased during disc degeneration.
Title: Expression of ADAMTS-7 and ADAMTS-12 in the nucleus pulposus during degeneration of rat caudal intervetebral disc.
ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.
Title: ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.
ADAMTS-7 is the first metalloproteinase found to bind directly to and degrade COMP
Title: ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 7

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7

NP_001040566.1

EC 3.4.24.-

NP_001380768.1

EC 3.4.24.-

NP_001380769.1

EC 3.4.24.-

XP_006243586.1

EC 3.4.24.-

XP_006243588.1

EC 3.4.24.-

XP_017451160.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047101.2 → NP_001040566.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 1

See identical proteins and their annotated locations for NP_001040566.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5ZSM3

Related

ENSRNOP00000060069.1, ENSRNOT00000068394.4

Conserved Domains (6) summary

smart00209
Location:736 → 788

TSP1; Thrombospondin type 1 repeats

cd04273
Location:436 → 644

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:436 → 647

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:271 → 386

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:894 → 1004

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:690 → 724

ADAM_CR; ADAM cysteine-rich
NM_001393839.1 → NP_001380768.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I5ZSM3

Conserved Domains (7) summary

smart00209
Location:523 → 575

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:1077 → 1371

PHA03247; large tegument protein UL36; Provisional

cd04273
Location:223 → 431

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:681 → 791

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:34 → 174

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:446 → 510

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:805 → 859

TSP1_ADAMTS; Thrombospondin type 1 domain
NM_001393840.1 → NP_001380769.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q1EHB3, Q1XD63

UniProtKB/TrEMBL

A0A8I5ZSM3

Related

ENSRNOP00000081488.1, ENSRNOT00000118446.1

Conserved Domains (7) summary

smart00209
Location:523 → 575

TSP1; Thrombospondin type 1 repeats

PHA03247
Location:1003 → 1312

PHA03247; large tegument protein UL36; Provisional

cd04273
Location:223 → 431

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:681 → 791

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:34 → 174

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:446 → 510

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:805 → 859

TSP1_ADAMTS; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

99584529..99624132

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243524.3 → XP_006243586.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1

UniProtKB/TrEMBL

A0A140TAF3, A0A8I5ZSM3

Related

ENSRNOP00000037875.6

Conserved Domains (6) summary

smart00209
Location:523 → 575

TSP1; Thrombospondin type 1 repeats

cd04273
Location:223 → 431

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:223 → 434

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:58 → 173

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:681 → 791

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:477 → 511

ADAM_CR; ADAM cysteine-rich
XM_006243526.3 → XP_006243588.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X2

UniProtKB/TrEMBL

A0A8I5ZSM3

Conserved Domains (6) summary

smart00209
Location:523 → 575

TSP1; Thrombospondin type 1 repeats

cd04273
Location:223 → 431

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:223 → 434

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:58 → 173

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:681 → 791

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:477 → 511

ADAM_CR; ADAM cysteine-rich
XM_017595671.3 → XP_017451160.1 A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X3