U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brwd3 bromodomain and WD repeat domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317213, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Brwd3provided by RGD
Official Full Name
bromodomain and WD repeat domain containing 3provided by RGD
Primary source
RGD:1559445
See related
Ensembl:ENSRNOG00000002291 AllianceGenome:RGD:1559445
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559445
Summary
Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 93. Orthologous to human BRWD3 (bromodomain and WD repeat domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 116.7), Spleen (RPKM 38.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Brwd3 in Genome Data Viewer
Location:
Xq22
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (77843766..77937240, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (73768343..73861643, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (79817968..79909891, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene syntaxin-3-like Neighboring gene peptidylprolyl isomerase D, pseudogene 17 Neighboring gene uncharacterized LOC134484057 Neighboring gene high mobility group nucleosome binding domain 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
bromodomain and WD repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    77843766..77937240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773357.4 → XP_008771579.2  bromodomain and WD repeat-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZE0, D3Z8C5
    Related
    ENSRNOP00000050434.6
    Conserved Domains (4) summary
    cd05529
    Location:1129 → 1241
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:172 → 494
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:183 → 220
    7WD40; WD40 repeat [structural motif]
    cl02556
    Location:1300 → 1439
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  2. XM_039100563.2 → XP_038956491.1  bromodomain and WD repeat-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZE0, A0A8I6A4D5
    Related
    ENSRNOP00000086739.1
    Conserved Domains (4) summary
    cd05529
    Location:1129 → 1241
    Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...
    cd00200
    Location:172 → 494
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:183 → 220
    7WD40; WD40 repeat [structural motif]
    cl02556
    Location:1300 → 1439
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous