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ssh2a slingshot protein phosphatase 2a [ Danio rerio (zebrafish) ]

Gene ID: 325085, updated on 27-Mar-2024

Summary

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Official Symbol
ssh2aprovided by ZNC
Official Full Name
slingshot protein phosphatase 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3810
See related
Ensembl:ENSDARG00000088440 AllianceGenome:ZFIN:ZDB-GENE-030131-3810
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ssh2; wu:fc54g05
Summary
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ssh2a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28548625..28587088, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (28615752..28654281, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase interacting ArfGAP 1 Neighboring gene ankyrin repeat domain 13B Neighboring gene si:ch211-225b7.5 Neighboring gene solute carrier family 6 member 4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase Slingshot homolog 2
Names
slingshot homolog 2
slingshot homolog 2a
XP_001921323.1
XP_005157728.1
XP_021322116.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    28548625..28587088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001921288.7 → XP_001921323.1  protein phosphatase Slingshot homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M1QV03, X1WFY2
    Related
    ENSDARP00000129137.1, ENSDART00000156049.2
    Conserved Domains (3) summary
    cd11652
    Location:3 → 238
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:310 → 445
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:253 → 304
    DEK_C; DEK C terminal domain

  2. XM_005157671.4 → XP_005157728.1  protein phosphatase Slingshot homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4L4, E7FH10
    Related
    ENSDARP00000112052.1, ENSDART00000127845.3
    Conserved Domains (3) summary
    cd11652
    Location:12 → 245
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:317 → 452
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:260 → 311
    DEK_C; DEK C terminal domain

  3. XM_021466441.1 → XP_021322116.1  protein phosphatase Slingshot homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PIQ4
    Conserved Domains (3) summary
    cd11652
    Location:12 → 245
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:317 → 452
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:259 → 311
    DEK_C; DEK C terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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