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wee2 WEE2 oocyte meiosis inhibiting kinase [ Danio rerio (zebrafish) ]

Gene ID: 327471, updated on 27-Mar-2024

Summary

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Official Symbol
wee2provided by ZNC
Official Full Name
WEE2 oocyte meiosis inhibiting kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5682
See related
Ensembl:ENSDARG00000012718 AllianceGenome:ZFIN:ZDB-GENE-030131-5682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:5913035; wu:fi13b10; zgc:123074; si:ch211-238n5.5
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in regulation of meiosis I. Predicted to act upstream of or within meiotic cell cycle; mitotic cell cycle; and protein phosphorylation. Predicted to be active in nucleus. Orthologous to human WEE2 (WEE2 oocyte meiosis inhibiting kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See wee2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20560706..20565982)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20571640..20576916)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11 Neighboring gene BH3 interacting domain death agonist Neighboring gene BCL2 like 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation. Tamai TK, et al. J Biol Rhythms, 2012 Jun. PMID 22653891
  2. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC123074, MGC162002

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
wee1-like protein kinase 2
Names
WEE1 homolog 2
wee1-like protein kinase 1B
wee1B kinase
NP_001032299.2
NP_001038367.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037222.2 → NP_001032299.2  wee1-like protein kinase 2 isoform 1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    BX470166
    UniProtKB/Swiss-Prot
    Q1LX51
    Related
    ENSDARP00000121512.1, ENSDART00000136710.3
    Conserved Domains (3) summary
    cd14139
    Location:182 → 454
    PTKc_Wee1b; Catalytic domain of the Protein Tyrosine Kinase, Wee1b
    cl21499
    Location:428 → 511
    SPX; Domain found in Syg1, Pho81, XPR1, and related proteins
    pfam00069
    Location:189 → 455
    Pkinase; Protein kinase domain

  2. NM_001044902.1 → NP_001038367.1  wee1-like protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_001038367.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most exon which results in a different 5' UTR and use of an alternate start codon compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BX470166
    UniProtKB/Swiss-Prot
    A4IFZ5, Q1LX50, Q1LX51, Q32PP5
    Related
    ENSDARP00000109848.2, ENSDART00000121699.4
    Conserved Domains (3) summary
    cd14139
    Location:187 → 459
    PTKc_Wee1b; Catalytic domain of the Protein Tyrosine Kinase, Wee1b
    cl21499
    Location:433 → 516
    SPX; Domain found in Syg1, Pho81, XPR1, and related proteins
    pfam00069
    Location:194 → 460
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    20560706..20565982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    158766..164107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1LX51.2 GenPept UniProtKB/Swiss-Prot:Q1LX51

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