vapa VAMP (vesicle-associated membrane protein)-associated protein A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vapaprovided by ZNC
Official Full Name: VAMP (vesicle-associated membrane protein)-associated protein Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6540
See related: AllianceGenome:ZFIN:ZDB-GENE-030131-6540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65776; zgc:77382; wu:fa14e12
Summary: Acts upstream of or within regulation of heart contraction. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Is expressed in heart. Orthologous to human VAPA (VAMP associated protein A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (42073861..42075843)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (42133333..42166823)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vesicle-associated membrane protein-associated protein A; VAMP (vesicle-associated membrane protein)-associated protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199918.2 → NP_956212.2 vesicle-associated membrane protein-associated protein A

See identical proteins and their annotated locations for NP_956212.2

Status: VALIDATED

Source sequence(s)

BC065663

UniProtKB/TrEMBL

Q6P0D4

Conserved Domains (1) summary

pfam00635
Location:7 → 111

Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

42073861..42075843

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470247.1 → XP_021325922.1 VAMP (vesicle-associated membrane protein)-associated protein A

UniProtKB/TrEMBL

A0A8M9P606

Conserved Domains (1) summary

pfam00635
Location:7 → 101

Motile_Sperm; MSP (Major sperm protein) domain