serpinb1l3 serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: serpinb1l3provided by ZNC
Official Full Name: serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7059
See related: Ensembl:ENSDARG00000014556 AllianceGenome:ZFIN:ZDB-GENE-030131-7059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fk71e06; zgc:64178; wu:fk71e06
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in extracellular space. Is expressed in gut and intestinal bulb. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to several human genes including SERPINB8 (serpin family B member 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (42148140..42157919)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (42226407..42236180)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SERPINB7 mutation causes Nagashima-type palmoplantar keratosis and its spatiotemporal expression in zebrafish.
Title: SERPINB7 mutation causes Nagashima-type palmoplantar keratosis and its spatiotemporal expression in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G40968 (e-PCR)
- UniSTS:34309

fk71e06.x1 (e-PCR)
- UniSTS:201460

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199936.1 → NP_956230.1 serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3

See identical proteins and their annotated locations for NP_956230.1

Status: PROVISIONAL

Source sequence(s)

BC053300

UniProtKB/TrEMBL

A0A8N7UZX4, Q7T309

Related

ENSDARP00000027639.6, ENSDART00000010658.9

Conserved Domains (1) summary

cl00137
Location:4 → 380

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

42148140..42157919

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005174205.4 → XP_005174262.1 serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3 isoform X1

UniProtKB/TrEMBL

A0A8M2BLG1

Conserved Domains (1) summary

cl00137
Location:39 → 415

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...