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MED21 Mediator complex subunit 21 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3354977, updated on 10-May-2024

Summary

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Official Symbol
MED21provided by FlyBase
Official Full Name
Mediator complex subunit 21provided by FlyBase
Primary source
FLYBASE:FBgn0040020
Locus tag
Dmel_CG17397
See related
AllianceGenome:FB:FBgn0040020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17397; CG40364; Dmel\CG17397; dSRB7; dTRAP19; med21; Med21; p18; Trap19
Summary
Enables transcription coregulator activity. Contributes to transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See MED21 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25114924..25115946, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (600380..601402, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46483 Neighboring gene NADH dehydrogenase (ubiquinone) AGGG subunit Neighboring gene SET domain containing 1 Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Park JM, et al. Mol Cell Biol, 2003 Feb. PMID 12556495, Free PMC Article
  2. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Pek JW, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21730191, Free PMC Article
  3. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Park JM, et al. Mol Cell, 2001 Jul. PMID 11511356
  4. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article
  5. Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males. Koya SK, et al. PLoS One, 2015. PMID 26468879, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit 21
Names
CG17397-PA
CG17397-PB
MED21-PA
MED21-PB
mediator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    25114924..25115946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015224.3 → NP_001015224.1  mediator complex subunit 21, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015224.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y534, Q9W5P1
    UniProtKB/TrEMBL
    A0A1B2AKZ9
    Conserved Domains (1) summary
    pfam11221
    Location:1 → 128
    Med21; Subunit 21 of Mediator complex

  2. NM_001015223.3 → NP_001015223.1  mediator complex subunit 21, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015223.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8Y534, Q9W5P1
    UniProtKB/TrEMBL
    A0A1B2AKZ9
    Conserved Domains (1) summary
    pfam11221
    Location:1 → 128
    Med21; Subunit 21 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W5P1.1 Q9W5P1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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