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CG40045 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355079, updated on 10-May-2024

Summary

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Official Symbol
CG40045provided by FlyBase
Primary source
FLYBASE:FBgn0058045
Locus tag
Dmel_CG40045
See related
AllianceGenome:FB:FBgn0058045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE63412; Dmel\CG40045; Ube2G1
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Is expressed in adult head. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG40045 in Genome Data Viewer
Location:
80F9-80F9; 3-47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (24028515..24035859)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (24021615..24028959)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43942 Neighboring gene long non-coding RNA:CR40053 Neighboring gene Synaptosomal-associated protein 25kDa Neighboring gene long non-coding RNA:CR45159 Neighboring gene neverland

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646
  2. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
  3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
  4. FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction. Gupta A, et al. Elife, 2020 Jun 11. PMID 32525804, Free PMC Article
  5. A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development. Franco M, et al. Mol Cell Proteomics, 2011 May. PMID 20861518, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG40045-PA
CG40045-PB
CG40045-PC
CG40045-PD
NP_001036640.1
NP_001246897.1
NP_001262239.1
NP_001262240.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    24028515..24035859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259968.1 → NP_001246897.1  uncharacterized protein Dmel_CG40045, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DME9
    Conserved Domains (1) summary
    pfam00179
    Location:1 → 89
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_001275310.1 → NP_001262239.1  uncharacterized protein Dmel_CG40045, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262239.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDD4
    Conserved Domains (2) summary
    COG5078
    Location:12 → 127
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:12 → 124
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_001043175.2 → NP_001036640.1  uncharacterized protein Dmel_CG40045, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036640.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYG3
    Conserved Domains (1) summary
    pfam00179
    Location:10 → 160
    UQ_con; Ubiquitin-conjugating enzyme

  4. NM_001275311.1 → NP_001262240.1  uncharacterized protein Dmel_CG40045, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262240.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG40
    Conserved Domains (2) summary
    COG5078
    Location:1 → 162
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:10 → 159
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3DME9 D3DME9
M9PDD4 M9PDD4
M9PG40 M9PG40
Q8SYG3 Q8SYG3

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