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rcbtb1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 336007, updated on 27-Mar-2024

Summary

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Official Symbol
rcbtb1provided by ZNC
Official Full Name
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7951
See related
Ensembl:ENSDARG00000036645 AllianceGenome:ZFIN:ZDB-GENE-030131-7951
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj43a07; zgc:56037; wu:fj43a07
Summary
Acts upstream of or within blood vessel development and retina vasculature development in camera-type eye. Predicted to be active in cytoplasm. Orthologous to human RCBTB1 (RCC1 and BTB domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rcbtb1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (46635236..46650083, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (45944004..45958835, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39-like Neighboring gene cytidine and dCMP deaminase domain containing 1 Neighboring gene ADP-ribosylation factor-like 11 Neighboring gene EBP like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of RCBTB1 is associated with Coats disease and familial exudative vitreoretinopathy. Wu JH, et al. Hum Mol Genet, 2016 Apr 15. PMID 26908610
  2. The 13q and 11q B-cell chronic lymphocytic leukaemia-associated regions derive from a common ancestral region in the zebrafish. Auer RL, et al. Br J Haematol, 2007 Jun. PMID 17488487
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina vasculature development in camera-type eye IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
RCC1 and BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199991.1 → NP_956285.1  RCC1 and BTB domain-containing protein 1

    See identical proteins and their annotated locations for NP_956285.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045877
    UniProtKB/TrEMBL
    Q7ZVG0
    Related
    ENSDARP00000053221.5, ENSDART00000053222.7
    Conserved Domains (5) summary
    smart00225
    Location:371 → 467
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd14821
    Location:467 → 525
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:199 → 248
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:360 → 464
    BTB; BTB/POZ domain
    pfam13540
    Location:77 → 106
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    46635236..46650083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170970.4 → XP_005171027.1  RCC1 and BTB domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BI84, B8A4R1
    Conserved Domains (5) summary
    smart00225
    Location:371 → 467
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd14821
    Location:467 → 525
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:199 → 248
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:360 → 464
    BTB; BTB/POZ domain
    pfam13540
    Location:77 → 106
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
Nucleotide Protein Strain
Heading Accession and Version

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