napsa napsin A aspartic peptidase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: napsaprovided by ZNC
Official Full Name: napsin A aspartic peptidaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8690
See related: Ensembl:ENSDARG00000009313 AllianceGenome:ZFIN:ZDB-GENE-030131-8690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa94d12; zgc:63831; wu:fa94d12
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in lysosome. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (25121365..25133244)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (24990817..25002696)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: napsin-A

NP_956325.1

EC 3.4.23.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200031.1 → NP_956325.1 napsin-A precursor

See identical proteins and their annotated locations for NP_956325.1

Status: PROVISIONAL

Source sequence(s)

BC056836

UniProtKB/TrEMBL

Q6PGT7

Related

ENSDARP00000012342.6, ENSDART00000025724.7

Conserved Domains (3) summary

cd05490
Location:86 → 410

Cathepsin_D2; Cathepsin_D2, pepsin family of proteinases

pfam00026
Location:91 → 411

Asp; Eukaryotic aspartyl protease

pfam07966
Location:21 → 48

A1_Propeptide; A1 Propeptide