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brd8b bromodomain containing 8b [ Danio rerio (zebrafish) ]

Gene ID: 337414, updated on 27-Mar-2024

Summary

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Official Symbol
brd8bprovided by ZNC
Official Full Name
bromodomain containing 8bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030722-10
See related
Ensembl:ENSDARG00000025071 AllianceGenome:ZFIN:ZDB-GENE-030722-10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
brd8; cb555; zgc:66249; wu:fj66h01; wu:fj84g12
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in nervous system; pectoral fin musculature; pharyngeal arch 3-7 skeleton; post-vent region; and primordial germ cell. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See brd8b in Genome Data Viewer
Location:
chromosome: 14
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7697694..7740058)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (7391287..7433794)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene GDNF family receptor alpha 3 Neighboring gene uncharacterized LOC108192140 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene si:ch211-39i2.2 Neighboring gene stimulator of interferon response cGAMP interactor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Chronic PFOS Exposure Disrupts Thyroid Structure and Function in Zebrafish. Chen J, et al. Bull Environ Contam Toxicol, 2018 Jul. PMID 29802430
  2. Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I. Biacchesi S, et al. PLoS One, 2012. PMID 23091644, Free PMC Article
  3. Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Yang L, et al. Toxicol Sci, 2010 Jun. PMID 20181659
  4. Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. De Wit M, et al. Chemosphere, 2008 Dec. PMID 18976794
  5. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bromodomain-containing protein 8
Names
bromodomain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212777.1 → NP_997942.1  bromodomain-containing protein 8

    See identical proteins and their annotated locations for NP_997942.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057496
    UniProtKB/TrEMBL
    Q6PFM2
    Related
    ENSDARP00000031318.6, ENSDART00000028623.8
    Conserved Domains (2) summary
    cd05507
    Location:633 → 736
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    pfam08890
    Location:42 → 112
    Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    7697694..7740058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358993.2 → XP_017214482.1  bromodomain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z445

  2. XM_017358992.2 → XP_017214481.1  bromodomain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z2L2

  3. XM_005157127.4 → XP_005157184.1  bromodomain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B3X0
    Conserved Domains (2) summary
    cd05507
    Location:664 → 767
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    pfam08890
    Location:73 → 143
    Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

  4. XM_005157128.4 → XP_005157185.1  bromodomain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    A0A8M2B380
    Conserved Domains (2) summary
    cd05507
    Location:664 → 767
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    pfam08890
    Location:73 → 143
    Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

  5. XM_005157131.4 → XP_005157188.1  bromodomain-containing protein 8 isoform X6

    UniProtKB/TrEMBL
    A0A8M2B3A4
    Related
    ENSDARP00000111047.3, ENSDART00000123139.4
    Conserved Domains (2) summary
    cd05507
    Location:664 → 767
    Bromo_brd8_like; Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be ...
    pfam08890
    Location:73 → 143
    Phage_TAC_5; Phage XkdN-like tail assembly chaperone protein, TAC

  6. XM_017358995.2 → XP_017214484.1  bromodomain-containing protein 8 isoform X5

    UniProtKB/TrEMBL
    A0A8M6Z9T3
Nucleotide Protein Strain
Heading Accession and Version

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