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Cdc23 Cell division cycle 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35315, updated on 10-May-2024

Summary

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Official Symbol
Cdc23provided by FlyBase
Official Full Name
Cell division cycle 23provided by FlyBase
Primary source
FLYBASE:FBgn0032863
Locus tag
Dmel_CG2508
See related
AllianceGenome:FB:FBgn0032863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38C.54; Apc8; APC8; APC8 (cdc23); cdc23; CDC23; CG2508; CG2508-PA; Dmel\CG2508
Summary
Involved in endomitotic cell cycle and positive regulation of mitotic metaphase/anaphase transition. Part of anaphase-promoting complex. Is expressed in organism. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Cdc23 in Genome Data Viewer
Location:
38C7-38C8; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20459342..20461729)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20459342..20461729)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44980 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43234 Neighboring gene long non-coding RNA:CR46416 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. Pál M, et al. J Cell Sci, 2007 Sep 15. PMID 17878237
  2. Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion. Silva RD, et al. Curr Biol, 2018 Sep 10. PMID 30122528, Free PMC Article
  3. A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. Whitfield ZJ, et al. PLoS Biol, 2013 Sep. PMID 24019759, Free PMC Article
  4. APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Narbonne-Reveau K, et al. Development, 2008 Apr. PMID 18321983
  5. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Mohd-Sarip A, et al. Science, 2012 May 11. PMID 22491092

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apc6/Cdc16 and Apc8/Cdc23 silencing induces developmental delay and causes different pupal lethality
    Title: Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endomitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle 23
Names
CG2508-PA
CG2508-PB
Cdc23-PA
Cdc23-PB
cdc23
cell division cycle 23 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20459342..20461729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136192.3 → NP_610036.2  cell division cycle 23, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610036.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A417, Q9I7L8
    Related
    FBpp0080894
    Conserved Domains (3) summary
    COG0457
    Location:235 → 507
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:318 → 346
    TPR; TPR repeat [structural motif]
    pfam04049
    Location:11 → 119
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

  2. NM_001273700.1 → NP_001260629.1  cell division cycle 23, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260629.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8A417, Q9I7L8
    Conserved Domains (3) summary
    COG0457
    Location:235 → 507
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:318 → 346
    TPR; TPR repeat [structural motif]
    pfam04049
    Location:11 → 119
    ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I7L8 Q9I7L8

Gene LinkOut

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