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nkcc-1 Solute carrier family 12 member 1 [ Caenorhabditis elegans ]

Gene ID: 3565648, updated on 12-Jun-2024

Summary

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Gene symbol
nkcc-1
Gene description
Solute carrier family 12 member 1
Locus tag
CELE_Y37A1C.1
See related
AllianceGenome:WB:WBGene00012543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in body wall musculature; intestine; neurons; oocyte; and vulval muscle. Human ortholog(s) of this gene implicated in Bartter disease; Bartter disease type 1; Gitelman syndrome; autosomal dominant nonsyndromic deafness 78; and essential hypertension. Orthologous to human SLC12A1 (solute carrier family 12 member 1); SLC12A2 (solute carrier family 12 member 2); and SLC12A3 (solute carrier family 12 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nkcc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
18
Sequence:
Chromosome: IV; NC_003282.8 (14107720..14124056, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans. Han B, et al. Genetics, 2015 Apr. PMID 25644702, Free PMC Article
  2. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Ji W, et al. Nat Genet, 2008 May. PMID 18391953, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Solute carrier family 12 member 1
NP_001076724.1
  • Confirmed by transcript evidence
NP_001255788.1
  • Confirmed by transcript evidence
NP_001255789.1
  • Confirmed by transcript evidence
NP_001255790.1
  • Partially confirmed by transcript evidence
NP_001255791.1
  • Confirmed by transcript evidence
NP_001263812.1
  • Confirmed by transcript evidence
NP_502704.1
  • Partially confirmed by transcript evidence
NP_502705.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14107720..14124056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268862.4 → NP_001255791.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8ESD4
    Conserved Domains (3) summary
    TIGR00930
    Location:141 → 1186
    2a30; K-Cl cotransporter
    pfam03522
    Location:727 → 1186
    SLC12; Solute carrier family 12
    cl00456
    Location:299 → 662
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001276883.3 → NP_001263812.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8E912
    Conserved Domains (3) summary
    TIGR00930
    Location:143 → 1188
    2a30; K-Cl cotransporter
    pfam03522
    Location:729 → 1188
    SLC12; Solute carrier family 12
    cl00456
    Location:301 → 664
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001268861.4 → NP_001255790.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8ESD5
    Conserved Domains (3) summary
    TIGR00930
    Location:165 → 1235
    2a30; K-Cl cotransporter
    pfam03522
    Location:751 → 1235
    SLC12; Solute carrier family 12
    cl00456
    Location:323 → 686
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_001083255.4 → NP_001076724.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEQ4
    Conserved Domains (3) summary
    TIGR00930
    Location:165 → 1210
    2a30; K-Cl cotransporter
    pfam03522
    Location:751 → 1210
    SLC12; Solute carrier family 12
    cl00456
    Location:323 → 686
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. NM_001268859.3 → NP_001255788.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255788.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P897
    Conserved Domains (2) summary
    TIGR00930
    Location:1 → 870
    2a30; K-Cl cotransporter
    pfam03522
    Location:411 → 870
    SLC12; Solute carrier family 12

  6. NM_001268860.3 → NP_001255789.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P898
    Conserved Domains (1) summary
    pfam03522
    Location:89 → 548
    SLC12; Solute carrier family 12

  7. NM_070303.2 → NP_502704.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFE5
    Conserved Domains (3) summary
    pfam00324
    Location:249 → 742
    AA_permease; Amino acid permease
    pfam03522
    Location:751 → 886
    SLC12; Solute carrier family 12
    cl00456
    Location:323 → 686
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. NM_070304.1 → NP_502705.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502705.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFN5
Nucleotide Protein
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