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CG14744 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35858, updated on 10-May-2024

Summary

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Official Symbol
CG14744provided by FlyBase
Primary source
FLYBASE:FBgn0033324
Locus tag
Dmel_CG14744
See related
AllianceGenome:FB:FBgn0033324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14744
Summary
Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in cation transport and cellular calcium ion homeostasis. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG14744 in Genome Data Viewer
Location:
44E2-44E2; 2-59 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8706388..8709486, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4593893..4596991, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SC1a Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. Paredes JC, et al. Immunity, 2011 Nov 23. PMID 22118526
  2. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
  3. Function-informed transcriptome analysis of Drosophila renal tubule. Wang J, et al. Genome Biol, 2004. PMID 15345053, Free PMC Article
  4. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14744-PC
CG14744-PD
CG14744-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8706388..8709486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299278.1 → NP_001286207.1  uncharacterized protein Dmel_CG14744, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEV7
    Conserved Domains (1) summary
    pfam01699
    Location:79 → 221
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_001103762.3 → NP_001097232.2  uncharacterized protein Dmel_CG14744, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097232.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7I1
    Conserved Domains (1) summary
    pfam01699
    Location:450 → 601
    Na_Ca_ex; Sodium/calcium exchanger protein

  3. NM_001299279.1 → NP_001286208.1  uncharacterized protein Dmel_CG14744, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEG9
    Conserved Domains (1) summary
    pfam01699
    Location:79 → 221
    Na_Ca_ex; Sodium/calcium exchanger protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEG9 A0A0B4LEG9
A0A0B4LEV7 A0A0B4LEV7
A1Z7I1 A1Z7I1

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