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tfpia tissue factor pathway inhibitor a [ Danio rerio (zebrafish) ]

Gene ID: 359833, updated on 27-Mar-2024

Summary

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Official Symbol
tfpiaprovided by ZNC
Official Full Name
tissue factor pathway inhibitor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030711-1
See related
Ensembl:ENSDARG00000034718 AllianceGenome:ZFIN:ZDB-GENE-030711-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TFPI; tfpib; wu:fb92g01; zgc:152844; zgc:158592; si:dz44f8.1
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in blood coagulation. Predicted to act upstream of or within hemostasis and negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in caudal fin skeleton. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See tfpia in Genome Data Viewer
Location:
chromosome: 9
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (42420636..42484444, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (42618849..42682657, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkey-10c21.1 Neighboring gene calcitonin receptor-like a Neighboring gene uncharacterized LOC103911686 Neighboring gene GULP PTB domain containing engulfment adaptor 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Knockdown and Knockout of Tissue Factor Pathway Inhibitor in Zebrafish. Raman R, et al. Thromb Haemost, 2022 Jul. PMID 34918310
  2. 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Schmid S, et al. Environ Pollut, 2020 Apr. PMID 31887585
  3. Calcitonin receptor family evolution and fishing for function using in silico promoter analysis. Martins R, et al. Gen Comp Endocrinol, 2014 Dec 1. PMID 24815885
  4. Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors. Joris M, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934490, Free PMC Article
  5. Identification of a new adtrp1-tfpi regulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis. Wang L, et al. FASEB J, 2018 Jan. PMID 28877957, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tissue factor pathway inhibitor a
Names
coagulation inhibitor
lipoprotein-associated
tissue factor pathway inhibitor b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309803.1 → NP_001296732.1  tissue factor pathway inhibitor a isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX470245, CT943665
    UniProtKB/TrEMBL
    A0A8M1P282, B0S6C1
    Related
    ENSDARP00000047652.6, ENSDART00000047653.8
    Conserved Domains (2) summary
    cd00109
    Location:99 → 151
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:42 → 92
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. NM_182872.2 → NP_878292.2  tissue factor pathway inhibitor a isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BX470245, CT943665
    UniProtKB/TrEMBL
    A0A8M1PAQ1, E7EXD1
    Related
    ENSDARP00000048319.7, ENSDART00000048320.7
    Conserved Domains (2) summary
    cd00109
    Location:98 → 150
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:41 → 91
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    42420636..42484444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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