U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pnpla6 patatin-like phospholipase domain containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360753, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
Pnpla6provided by RGD
Official Full Name
patatin-like phospholipase domain containing 6provided by RGD
Primary source
RGD:1564611
See related
Ensembl:ENSRNOG00000000977 AllianceGenome:RGD:1564611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564611
Summary
Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process and phosphatidylcholine metabolic process. Predicted to act upstream of or within angiogenesis and animal organ morphogenesis. Predicted to be located in cytosol and membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 66.1), Brain (RPKM 51.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pnpla6 in Genome Data Viewer
Location:
12p12
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (6372284..6401632)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1574387..1603735)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2068749..2098139)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 358 Neighboring gene mucolipin TRP cation channel 1 Neighboring gene uncharacterized LOC120095868 Neighboring gene calmodulin regulated spectrin-associated protein family, member 3 Neighboring gene XPA binding protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers. McFerrin J, et al. Glia, 2017 May. PMID 28206686, Free PMC Article
  2. Protein domains, catalytic activity, and subcellular distribution of neuropathy target esterase in Mammalian cells. Li Y, et al. J Biol Chem, 2003 Mar 7. PMID 12514188
  3. Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells. Zaccheo O, et al. J Biol Chem, 2004 Jun 4. PMID 15044461
  4. Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. Kienesberger PC, et al. J Biol Chem, 2008 Feb 29. PMID 18086666
  5. Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Moser M, et al. Mol Cell Biol, 2004 Feb. PMID 14749382, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lysophospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
patatin-like phospholipase domain-containing protein 6
Names
neuropathy target esterase
NP_001414056.1
NP_001414057.1
XP_008767227.2
XP_008767229.1
XP_008767230.1
XP_008767231.2
XP_008767232.2
XP_008767234.1
XP_038945821.1
XP_038945823.1
XP_038945825.1
XP_063127495.1
XP_063127496.1
XP_063127497.1
XP_063127498.1
XP_063127499.1
XP_063127500.1
XP_063127501.1
XP_063127503.1
XP_063127504.1
XP_063127505.1
XP_063127506.1
XP_063127507.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427127.1 → NP_001414056.1  patatin-like phospholipase domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6KQ10

  2. NM_001427128.1 → NP_001414057.1  patatin-like phospholipase domain-containing protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6KQ10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    6372284..6401632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769010.4 → XP_008767232.2  patatin-like phospholipase domain-containing protein 6 isoform X12

    UniProtKB/TrEMBL
    A6KQ10, D3ZRF6
    Conserved Domains (4) summary
    cd07225
    Location:938 → 1243
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:162 → 304
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:943 → 1227
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:609 → 717
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. XM_063271431.1 → XP_063127501.1  patatin-like phospholipase domain-containing protein 6 isoform X10

    UniProtKB/TrEMBL
    A6KQ10

  3. XM_008769009.4 → XP_008767231.2  patatin-like phospholipase domain-containing protein 6 isoform X12

    UniProtKB/TrEMBL
    A6KQ10, D3ZRF6
    Related
    ENSRNOP00000001298.6
    Conserved Domains (4) summary
    cd07225
    Location:938 → 1243
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:162 → 304
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:943 → 1227
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:609 → 717
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  4. XM_063271436.1 → XP_063127506.1  patatin-like phospholipase domain-containing protein 6 isoform X14

    UniProtKB/TrEMBL
    A6KQ10

  5. XM_063271434.1 → XP_063127504.1  patatin-like phospholipase domain-containing protein 6 isoform X13

    UniProtKB/TrEMBL
    A6KQ09, A6KQ10

  6. XM_063271430.1 → XP_063127500.1  patatin-like phospholipase domain-containing protein 6 isoform X10

    UniProtKB/TrEMBL
    A6KQ10

  7. XM_008769012.4 → XP_008767234.1  patatin-like phospholipase domain-containing protein 6 isoform X13

    See identical proteins and their annotated locations for XP_008767234.1

    UniProtKB/TrEMBL
    A6KQ09, A6KQ10
    Conserved Domains (4) summary
    cd07225
    Location:937 → 1242
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:162 → 304
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:942 → 1226
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:609 → 717
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  8. XM_039089897.2 → XP_038945825.1  patatin-like phospholipase domain-containing protein 6 isoform X15

    UniProtKB/TrEMBL
    A6KQ10
    Conserved Domains (2) summary
    cd07225
    Location:933 → 1238
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    cd00038
    Location:605 → 713
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  9. XM_063271437.1 → XP_063127507.1  patatin-like phospholipase domain-containing protein 6 isoform X16

    UniProtKB/TrEMBL
    A6KQ10

  10. XM_063271433.1 → XP_063127503.1  patatin-like phospholipase domain-containing protein 6 isoform X12

    UniProtKB/TrEMBL
    A6KQ10, D3ZRF6

  11. XM_063271435.1 → XP_063127505.1  patatin-like phospholipase domain-containing protein 6 isoform X13

    UniProtKB/TrEMBL
    A6KQ09, A6KQ10

  12. XM_063271425.1 → XP_063127495.1  patatin-like phospholipase domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A6KQ10

  13. XM_008769005.4 → XP_008767227.2  patatin-like phospholipase domain-containing protein 6 isoform X7

    UniProtKB/TrEMBL
    A6KQ10

  14. XM_063271426.1 → XP_063127496.1  patatin-like phospholipase domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    A6KQ10

  15. XM_008769007.4 → XP_008767229.1  patatin-like phospholipase domain-containing protein 6 isoform X6

    See identical proteins and their annotated locations for XP_008767229.1

    UniProtKB/TrEMBL
    A6KQ10
    Conserved Domains (4) summary
    cd07225
    Location:949 → 1254
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:173 → 315
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:954 → 1238
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:620 → 728
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  16. XM_039089893.2 → XP_038945821.1  patatin-like phospholipase domain-containing protein 6 isoform X9

    UniProtKB/TrEMBL
    A6KQ10
    Conserved Domains (2) summary
    cd07225
    Location:948 → 1253
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    cd00038
    Location:620 → 728
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  17. XM_063271427.1 → XP_063127497.1  patatin-like phospholipase domain-containing protein 6 isoform X3

    UniProtKB/TrEMBL
    A6KQ10

  18. XM_008769008.4 → XP_008767230.1  patatin-like phospholipase domain-containing protein 6 isoform X8

    See identical proteins and their annotated locations for XP_008767230.1

    UniProtKB/TrEMBL
    A6KQ10, M0R715
    Related
    ENSRNOP00000065231.2
    Conserved Domains (4) summary
    cd07225
    Location:948 → 1253
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    COG0664
    Location:173 → 315
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    COG1752
    Location:953 → 1237
    RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
    cd00038
    Location:620 → 728
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  19. XM_063271428.1 → XP_063127498.1  patatin-like phospholipase domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A6KQ10

  20. XM_063271429.1 → XP_063127499.1  patatin-like phospholipase domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A6KQ10

  21. XM_039089895.2 → XP_038945823.1  patatin-like phospholipase domain-containing protein 6 isoform X11

    UniProtKB/TrEMBL
    A6KQ10
    Conserved Domains (2) summary
    cd07225
    Location:944 → 1249
    Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
    cd00038
    Location:616 → 724
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous