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Sun1 Sad1 and UNC84 domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360773, updated on 25-Apr-2024

Summary

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Official Symbol
Sun1provided by RGD
Official Full Name
Sad1 and UNC84 domain containing 1provided by RGD
Primary source
RGD:1359142
See related
Ensembl:ENSRNOG00000001299 AllianceGenome:RGD:1359142
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Unc84a
Summary
Predicted to enable cytoskeleton-nuclear membrane anchor activity and lamin binding activity. Involved in ossification and response to mechanical stimulus. Located in nucleus. Orthologous to human SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 96.1), Heart (RPKM 86.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sun1 in Genome Data Viewer
Location:
12q11
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20510230..20555123, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15396378..15441277, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17488482..17533334, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene uncharacterized LOC102547493 Neighboring gene dynein, axonemal, assembly factor 5 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC103691050

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment. Sharma VP, et al. Cells, 2021 Jun 19. PMID 34205257, Free PMC Article
  2. Lacunocanalicular fluid flow transduces mechanical tension stress during distraction osteogenesis. Davidson EH, et al. J Craniofac Surg, 2013 Sep. PMID 24036726
  3. Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. Link J, et al. PLoS Genet, 2014 Feb. PMID 24586178, Free PMC Article
  4. Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Chen CY, et al. Cell, 2012 Apr 27. PMID 22541428, Free PMC Article
  5. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. Horn HF, et al. J Cell Biol, 2013 Sep 30. PMID 24062341, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment.
    Title: SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94535

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic attachment of telomere to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear matrix anchoring at nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration ISO
Inferred from Sequence Orthology
more info
  
involved_in ossification IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of meiotic nuclear membrane microtubule tethering complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SUN domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007147.1 → NP_001007148.1  SUN domain-containing protein 1

    See identical proteins and their annotated locations for NP_001007148.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085844
    UniProtKB/TrEMBL
    A0A8I6AQ96, Q5U2W0
    Related
    ENSRNOP00000045984.2, ENSRNOT00000047287.3
    Conserved Domains (2) summary
    pfam07738
    Location:621 → 755
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:74 → 259
    MRP; Mitochondrial RNA binding protein MRP

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    20510230..20555123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271462.1 → XP_063127532.1  SUN domain-containing protein 1 isoform X10

  2. XM_063271458.1 → XP_063127528.1  SUN domain-containing protein 1 isoform X4

  3. XM_039089559.2 → XP_038945487.1  SUN domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (4) summary
    COG1196
    Location:493 → 668
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:784 → 918
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:69 → 422
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:560 → 613
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  4. XM_063271466.1 → XP_063127536.1  SUN domain-containing protein 1 isoform X18

  5. XM_039089565.2 → XP_038945493.1  SUN domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I6A5M4, A6K1X2
    Conserved Domains (4) summary
    COG1196
    Location:458 → 641
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:741 → 875
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:93 → 380
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:518 → 569
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  6. XM_006248949.5 → XP_006249011.1  SUN domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I6A5M4, A0A8I6AAB7, A6K1X2
    Related
    ENSRNOP00000088736.1
    Conserved Domains (2) summary
    pfam07738
    Location:742 → 876
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 380
    MRP; Mitochondrial RNA binding protein MRP

  7. XM_063271460.1 → XP_063127530.1  SUN domain-containing protein 1 isoform X8

  8. XM_006248948.5 → XP_006249010.1  SUN domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ALL7, A6K1X3
    Conserved Domains (2) summary
    pfam07738
    Location:771 → 905
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 409
    MRP; Mitochondrial RNA binding protein MRP

  9. XM_063271459.1 → XP_063127529.1  SUN domain-containing protein 1 isoform X6

  10. XM_006248942.5 → XP_006249004.1  SUN domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K016, A0A8I6A5F2
    Related
    ENSRNOP00000088072.1
    Conserved Domains (2) summary
    pfam07738
    Location:807 → 941
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 265
    MRP; Mitochondrial RNA binding protein MRP

  11. XM_006248941.5 → XP_006249003.1  SUN domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (2) summary
    pfam07738
    Location:808 → 942
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 265
    MRP; Mitochondrial RNA binding protein MRP

  12. XM_063271470.1 → XP_063127540.1  SUN domain-containing protein 1 isoform X24

  13. XM_006248953.5 → XP_006249015.1  SUN domain-containing protein 1 isoform X23

    UniProtKB/TrEMBL
    A0A8I6AQ96
    Related
    ENSRNOP00000096888.1
    Conserved Domains (2) summary
    pfam07738
    Location:650 → 784
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 288
    MRP; Mitochondrial RNA binding protein MRP

  14. XM_063271469.1 → XP_063127539.1  SUN domain-containing protein 1 isoform X22

  15. XM_006248952.5 → XP_006249014.1  SUN domain-containing protein 1 isoform X21

    UniProtKB/TrEMBL
    A0A8I6A5M4, A6K1X2
    Related
    ENSRNOP00000087314.1
    Conserved Domains (2) summary
    pfam07738
    Location:683 → 817
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 321
    MRP; Mitochondrial RNA binding protein MRP

  16. XM_006248951.5 → XP_006249013.1  SUN domain-containing protein 1 isoform X17

    UniProtKB/TrEMBL
    A0A8I6A5M4, A6K1X2
    Conserved Domains (2) summary
    pfam07738
    Location:705 → 839
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:103 → 343
    MRP; Mitochondrial RNA binding protein MRP

  17. XM_063271468.1 → XP_063127538.1  SUN domain-containing protein 1 isoform X20

  18. XM_063271467.1 → XP_063127537.1  SUN domain-containing protein 1 isoform X19

  19. XM_063271464.1 → XP_063127534.1  SUN domain-containing protein 1 isoform X15

  20. XM_008768984.4 → XP_008767206.1  SUN domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (2) summary
    pfam07738
    Location:729 → 863
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:24 → 186
    MRP; Mitochondrial RNA binding protein MRP

  21. XM_063271472.1 → XP_063127542.1  SUN domain-containing protein 1 isoform X26

  22. XM_039089561.2 → XP_038945489.1  SUN domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (4) summary
    COG1196
    Location:464 → 639
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:755 → 889
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:40 → 393
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:531 → 584
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  23. XM_039089560.2 → XP_038945488.1  SUN domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (4) summary
    COG1196
    Location:464 → 639
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:755 → 889
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:40 → 393
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:531 → 584
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  24. XM_039089566.2 → XP_038945494.1  SUN domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K016, A0A8I6APF3, A6K1X6
    Conserved Domains (4) summary
    COG1196
    Location:488 → 663
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:779 → 913
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:64 → 417
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:555 → 608
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  25. XM_006248946.4 → XP_006249008.1  SUN domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006249008.1

    UniProtKB/TrEMBL
    A0A0G2K016, A0A8I6APF3, A6K1X6
    Conserved Domains (4) summary
    COG1196
    Location:488 → 663
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:779 → 913
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:64 → 417
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:555 → 608
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  26. XM_006248943.4 → XP_006249005.1  SUN domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006249005.1

    UniProtKB/TrEMBL
    A0A0G2K016, A0A8I6APF3, A6K1X6
    Related
    ENSRNOP00000095673.1
    Conserved Domains (4) summary
    COG1196
    Location:488 → 663
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:779 → 913
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:64 → 417
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:555 → 608
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  27. XM_039089564.2 → XP_038945492.1  SUN domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (4) summary
    COG1196
    Location:464 → 639
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:755 → 889
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:40 → 393
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:531 → 584
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  28. XM_063271465.1 → XP_063127535.1  SUN domain-containing protein 1 isoform X16

  29. XM_063271471.1 → XP_063127541.1  SUN domain-containing protein 1 isoform X25

    UniProtKB/TrEMBL
    Q5U2W0

  30. XM_063271463.1 → XP_063127533.1  SUN domain-containing protein 1 isoform X13

  31. XM_006248945.4 → XP_006249007.1  SUN domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006249007.1

    UniProtKB/TrEMBL
    A0A0G2K016, A0A8I6APF3, A6K1X6
    Conserved Domains (4) summary
    COG1196
    Location:488 → 663
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:779 → 913
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:64 → 417
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:555 → 608
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  32. XM_063271461.1 → XP_063127531.1  SUN domain-containing protein 1 isoform X9

  33. XM_039089562.2 → XP_038945490.1  SUN domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (4) summary
    COG1196
    Location:464 → 639
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:755 → 889
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:40 → 393
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:531 → 584
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  34. XM_006248947.5 → XP_006249009.1  SUN domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006249009.1

    UniProtKB/TrEMBL
    A0A0G2K016, A0A8I6APF3, A6K1X6
    Conserved Domains (4) summary
    COG1196
    Location:488 → 663
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:779 → 913
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:64 → 417
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:555 → 608
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

  35. XM_039089567.2 → XP_038945495.1  SUN domain-containing protein 1 isoform X27

    UniProtKB/TrEMBL
    A0A0G2K016
    Conserved Domains (4) summary
    COG1196
    Location:299 → 474
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07738
    Location:590 → 724
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:190 → 228
    MRP; Mitochondrial RNA binding protein MRP
    cd21439
    Location:366 → 419
    SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins
Nucleotide Protein Strain
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