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Galntl6 polypeptide N-acetylgalactosaminyltransferase-like 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361142, updated on 30-Mar-2024

Summary

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Official Symbol
Galntl6provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase-like 6provided by RGD
Primary source
RGD:1564773
See related
Ensembl:ENSRNOG00000067282 AllianceGenome:RGD:1564773
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Galnt17; RGD1564773
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Orthologous to human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 38.8) and Heart (RPKM 1.4) See more
Orthologs
human mouse all
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Genomic context

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See Galntl6 in Genome Data Viewer
Location:
16p12-p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (36203674..37454709)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (31192880..32443979)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (34551052..35803840)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097434 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene myeloid-associated differentiation marker-like Neighboring gene U6atac minor spliceosomal RNA Neighboring gene ribosomal protein S27a, pseudogene 14 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134482370 Neighboring gene uncharacterized LOC120097422 Neighboring gene uncharacterized LOC120097421 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla. Zhang S, et al. Redox Biol, 2023 Aug. PMID 37315345, Free PMC Article
  2. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla.
    Title: CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase-like 6
Names
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
polypeptide N-acetylgalactosaminyltransferase 17
NP_001129228.1
XP_017455671.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135756.1 → NP_001129228.1  polypeptide N-acetylgalactosaminyltransferase-like 6

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZYW6
    Related
    ENSRNOP00000083243.1, ENSRNOT00000109059.1
    Conserved Domains (4) summary
    cd02510
    Location:143 → 438
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:456 → 584
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:454 → 582
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:140 → 365
    Glyco_tranf_2_3; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    36203674..37454709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600182.3 → XP_017455671.1  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYW6
    Conserved Domains (4) summary
    cd02510
    Location:143 → 438
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:456 → 584
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:454 → 582
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:140 → 365
    Glyco_tranf_2_3; Glycosyltransferase like family 2
Nucleotide Protein Strain
Heading Accession and Version

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