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Nudt12 nudix hydrolase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367323, updated on 11-Apr-2024

Summary

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Official Symbol
Nudt12provided by RGD
Official Full Name
nudix hydrolase 12provided by RGD
Primary source
RGD:1310902
See related
Ensembl:ENSRNOG00000022576 AllianceGenome:RGD:1310902
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding activity; and phosphodiesterase decapping endonuclease activity. Predicted to be involved in several processes, including RNA decapping; circadian regulation of gene expression; and nucleobase-containing compound catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in peroxisome. Orthologous to human NUDT12 (nudix hydrolase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 182.6), Liver (RPKM 90.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nudt12 in Genome Data Viewer
Location:
9q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (106188930..106202340, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (98741627..98755039, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (105680603..105693374, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480423 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene uncharacterized LOC108351976 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim SR, et al. Biochem J, 2003 Sep 1. PMID 12790796, Free PMC Article
  2. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Grudzien-Nogalska E, et al. Nat Chem Biol, 2019 Jun. PMID 31101919, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH pyrophosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA NAD-cap (NMN-forming) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphodiesterase decapping endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NAD catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD-cap decapping ISO
Inferred from Sequence Orthology
more info
  
involved_in NADH metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NADP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NADP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA methylguanosine-cap decapping ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NAD-capped RNA hydrolase NUDT12
Names
nudix (nucleoside diphosphate linked moiety X)-type motif 12
nudix-type motif 12
peroxisomal NADH pyrophosphatase NUDT12
NP_001102480.1
XP_006245650.1
XP_038939942.1
XP_038939943.1
XP_063123616.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109010.1 → NP_001102480.1  NAD-capped RNA hydrolase NUDT12

    See identical proteins and their annotated locations for NP_001102480.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473997
    UniProtKB/TrEMBL
    A6JR91, D4A2H8
    Related
    ENSRNOP00000061974.2, ENSRNOT00000066968.3
    Conserved Domains (7) summary
    COG2816
    Location:126 → 457
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:16 → 98
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323 → 457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:147 → 277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279 → 311
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:31 → 86
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:14 → 43
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    106188930..106202340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084015.2 → XP_038939943.1  NAD-capped RNA hydrolase NUDT12 isoform X3

    Conserved Domains (1) summary
    COG2816
    Location:110 → 312
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  2. XM_006245588.5 → XP_006245650.1  NAD-capped RNA hydrolase NUDT12 isoform X1

    See identical proteins and their annotated locations for XP_006245650.1

    UniProtKB/TrEMBL
    A6JR91, D4A2H8
    Conserved Domains (7) summary
    COG2816
    Location:126 → 457
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:16 → 98
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323 → 457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:147 → 277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279 → 311
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:31 → 86
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:14 → 43
    ANK; ANK repeat [structural motif]

  3. XM_039084014.2 → XP_038939942.1  NAD-capped RNA hydrolase NUDT12 isoform X3

    Conserved Domains (1) summary
    COG2816
    Location:110 → 312
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

  4. XM_063267546.1 → XP_063123616.1  NAD-capped RNA hydrolase NUDT12 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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