ube2h ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube2hprovided by ZNC
Official Full Name: ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-67
See related: Ensembl:ENSDARG00000000019 AllianceGenome:ZFIN:ZDB-GENE-030616-67
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc07a05; fi24c01; wu:fc07a05; wu:fi24c01; si:bz3c13.2
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (15011341..15059876)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (15012586..15061121)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish.
Title: A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fk40g03.x1 (e-PCR)
- UniSTS:200977

AW154232 (e-PCR)
- UniSTS:205919

fi24c01.x1 (e-PCR)
- UniSTS:197080

fc07a05.x1 (e-PCR)
- UniSTS:203741

fi86e02.y1 (e-PCR)
- UniSTS:198127

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: ubiquitin-conjugating enzyme E2 H

NP_958897.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201489.1 → NP_958897.1 ubiquitin-conjugating enzyme E2 H

See identical proteins and their annotated locations for NP_958897.1

Status: PROVISIONAL

Source sequence(s)

BC049139

UniProtKB/TrEMBL

B2GRU1, Q7ZUF3

Related

ENSDARP00000107407.2, ENSDART00000124452.3

Conserved Domains (2) summary

COG5078
Location:1 → 149

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

pfam00179
Location:31 → 145

UQ_con; Ubiquitin-conjugating enzyme