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eys eyes shut [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3771890, updated on 10-May-2024

Summary

Official Symbol
eysprovided by FlyBase
Official Full Name
eyes shutprovided by FlyBase
Primary source
FLYBASE:FBgn0031414
Locus tag
Dmel_CG33955
See related
AllianceGenome:FB:FBgn0031414
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
21A6; CG15388; CG15389; CG33955; CG7245; CT35437; Dmel\CG33955; Eyes Shut; Eys; EYS; mAb 21A6; mAb21A6; MAb21A6; spacemaker; spam; Spam; SPAM
Summary
An extracellular matrix structural constituent. Involved in cell morphogenesis; rhabdomere development; and temperature compensation of the circadian clock. Located in several cellular components, including cell surface; extracellular space; and non-motile cilium. Is expressed in adult head; dendritic cap cell; embryonic head sensory system; and sense organ. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 25. Orthologous to human EYS (eyes shut homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See eys in Genome Data Viewer
Location:
22E1-22E1; 2-6 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2311680..2358944)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2311680..2358944)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab5 Neighboring gene AXIN1 up-regulated 1

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
eyes shut
Names
CG33955-PE
CG33955-PF
Eye shut
agrin-like
eyeshut
eys-PE
eys-PF
fibropellin
spacemaker
spam

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2311680..2358944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032399.3NP_001027571.3  eyes shut, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027571.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1F4, Q06PM7, Q400N0, Q6IHY1, Q8MRJ7
    UniProtKB/TrEMBL
    M9PBU9
    Conserved Domains (4) summary
    cd00054
    Location:220256
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:19562144
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:15491578
    EGF; EGF-like domain
    pfam02210
    Location:17231856
    Laminin_G_2; Laminin G domain
  2. NM_001272995.1NP_001259924.2  eyes shut, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259924.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1F4, Q06PM7, Q400N0, Q6IHY1, Q8MRJ7
    UniProtKB/TrEMBL
    M9PBU9
    Conserved Domains (4) summary
    cd00054
    Location:220256
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:19562144
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:15491578
    EGF; EGF-like domain
    pfam02210
    Location:17231856
    Laminin_G_2; Laminin G domain