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prom1b prominin 1 b [ Danio rerio (zebrafish) ]

Gene ID: 378834, updated on 27-Mar-2024

Summary

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Official Symbol
prom1bprovided by ZNC
Official Full Name
prominin 1 bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031003-1
See related
Ensembl:ENSDARG00000034007 AllianceGenome:ZFIN:ZDB-GENE-031003-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
proml2
Summary
Predicted to enable cholesterol binding activity. Acts upstream of or within photoreceptor cell outer segment organization. Located in apical plasma membrane. Is expressed in nervous system; otic vesicle; and testis. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See prom1b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (22712925..22757213, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22022186..22066472, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor binding protein 2b Neighboring gene zinc finger, MYND-type containing 10 Neighboring gene transmembrane anterior posterior transformation 1b Neighboring gene LIM domain binding 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of the zebrafish CD133/prominin1 genes in cellular proliferation zones in the embryonic central nervous system and sensory organs. McGrail M, et al. Dev Dyn, 2010 Jun. PMID 20503380
  2. Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain. Jászai J, et al. PLoS One, 2013. PMID 23723983, Free PMC Article
  3. Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species. Jászai J, et al. PLoS One, 2011 Mar 2. PMID 21407811, Free PMC Article
  4. Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. Jászai J, et al. J Biol Chem, 2020 May 1. PMID 32201384, Free PMC Article
  5. Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. Clark BS, et al. Development, 2012 May. PMID 22492354, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prominin 1 b; prominin-1
Names
prominin-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198071.1 → NP_932337.1  prominin 1 b precursor

    See identical proteins and their annotated locations for NP_932337.1

    Status: PROVISIONAL

    Source sequence(s)
    AF373869
    UniProtKB/TrEMBL
    Q90WI3
    Related
    ENSDARP00000112980.1, ENSDART00000134719.3
    Conserved Domains (1) summary
    pfam05478
    Location:35 → 835
    Prominin; Prominin

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    22712925..22757213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481345.1 → XP_021337020.1  prominin-1 isoform X8

    UniProtKB/TrEMBL
    A0A8M9QPR6
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 834
    Prominin

  2. XM_021481324.1 → XP_021336999.1  prominin-1 isoform X6

    UniProtKB/TrEMBL
    A0A8M9QH22
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 840
    Prominin

  3. XM_021481302.1 → XP_021336977.1  prominin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q021
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 843
    Prominin

  4. XM_021481317.1 → XP_021336992.1  prominin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M9Q036
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 842
    Prominin

  5. XM_021481260.1 → XP_021336935.1  prominin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QPL4
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 848
    Prominin

  6. XM_021481275.1 → XP_021336950.1  prominin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QPM2
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 845
    Prominin

  7. XM_021481233.1 → XP_021336908.1  prominin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QBM3
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 851
    Prominin

  8. XM_005170913.3 → XP_005170970.1  prominin-1 isoform X7

    UniProtKB/TrEMBL
    A0A8M2BI60
    Conserved Domains (1) summary
    pfam05478
    Location:37 → 851
    Prominin; Prominin

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394480.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    47280..91394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395214.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    39288..83080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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