ddx49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddx49provided by ZNC
Official Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 49provided by ZNC
Primary source: ZFIN:ZDB-GENE-031030-3
See related: Ensembl:ENSDARG00000012899 AllianceGenome:ZFIN:ZDB-GENE-031030-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb82g04; wu:fd12e05
Summary: Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in rRNA processing. Predicted to be active in nucleus. Is expressed in female organism. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (6869312..6880725, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (6859473..6870886, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd12e05.x1 (e-PCR)
- UniSTS:195164

AI584733 (e-PCR)
- UniSTS:206233

fb82g04.y1 (e-PCR)
- UniSTS:191691

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX49

NP_938179.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198365.1 → NP_938179.1 probable ATP-dependent RNA helicase DDX49

See identical proteins and their annotated locations for NP_938179.1

Status: PROVISIONAL

Source sequence(s)

BC047834

UniProtKB/TrEMBL

Q7ZUT9

Related

ENSDARP00000015246.7, ENSDART00000007204.9

Conserved Domains (3) summary

PRK11192
Location:3 → 415

PRK11192; ATP-dependent RNA helicase SrmB; Provisional

cd00079
Location:218 → 351

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:4 → 206

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...