zbtb2a zinc finger and BTB domain containing 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zbtb2aprovided by ZNC
Official Full Name: zinc finger and BTB domain containing 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-726
See related: Ensembl:ENSDARG00000044038 AllianceGenome:ZFIN:ZDB-GENE-040426-726
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55511
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Orthologous to human ZBTB2 (zinc finger and BTB domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (7786254..7792573, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (7629069..7635256, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain containing 2a; zinc finger and BTB domain-containing protein 2a

Names: Zinc finger and BTB domain containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200160.1 → NP_956454.1 zinc finger and BTB domain-containing protein 2a

See identical proteins and their annotated locations for NP_956454.1

Status: PROVISIONAL

Source sequence(s)

BC045363

UniProtKB/TrEMBL

Q7ZVY4

Related

ENSDARP00000064654.3, ENSDART00000064655.4

Conserved Domains (4) summary

smart00225
Location:25 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:308 → 328

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:14 → 93

BTB; BTB/POZ domain

pfam13465
Location:320 → 342

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

7786254..7792573 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158599.4 → XP_005158656.1 zinc finger and BTB domain containing 2a isoform X1

UniProtKB/TrEMBL

A0A8M2B507, F1QX23

Conserved Domains (4) summary

smart00225
Location:25 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:308 → 328

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:14 → 93

BTB; BTB/POZ domain

pfam13465
Location:320 → 342

zf-H2C2_2; Zinc-finger double domain