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rnaseh2b ribonuclease H2, subunit B [ Danio rerio (zebrafish) ]

Gene ID: 393241, updated on 27-Mar-2024

Summary

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Official Symbol
rnaseh2bprovided by ZNC
Official Full Name
ribonuclease H2, subunit Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1090
See related
Ensembl:ENSDARG00000005128 AllianceGenome:ZFIN:ZDB-GENE-040426-1090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56602
Summary
Predicted to be involved in RNA catabolic process and ribonucleotide metabolic process. Predicted to be located in nucleus. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including alar plate midbrain region; blood; immature eye; nervous system; and ventral mesenchyme. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rnaseh2b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (29671506..29679173)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (29860771..29868502)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene microRNA 15a-2 Neighboring gene microRNA 16c Neighboring gene uncharacterized LOC110438837 Neighboring gene chromosome 9 CXorf21 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The 13q and 11q B-cell chronic lymphocytic leukaemia-associated regions derive from a common ancestral region in the zebrafish. Auer RL, et al. Br J Haematol, 2007 Jun. PMID 17488487
  2. Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation. Mueller RL, et al. BMC Genomics, 2010 Sep 9. PMID 20828405, Free PMC Article
  3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC56602

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease H2 subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200271.1 → NP_956565.1  ribonuclease H2 subunit B

    See identical proteins and their annotated locations for NP_956565.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049050
    UniProtKB/TrEMBL
    Q7ZUH0
    Conserved Domains (1) summary
    cd09270
    Location:1 → 208
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    29671506..29679173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167681.4 → XP_005167738.1  ribonuclease H2 subunit B isoform X2

    UniProtKB/TrEMBL
    A0A8M2BF43
    Conserved Domains (1) summary
    pfam09468
    Location:17 → 145
    RNase_H2-Ydr279; Ydr279p protein family (RNase H2 complex component)

  2. XM_021478630.1 → XP_021334305.1  ribonuclease H2 subunit B isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJJ8
    Related
    ENSDARP00000006173.5, ENSDART00000015377.7
    Conserved Domains (1) summary
    pfam09468
    Location:17 → 297
    RNase_H2-Ydr279; Ydr279p protein family (RNase H2 complex component)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394759.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    276943..284704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395285.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    35693..43360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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