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maco1a macoilin 1a [ Danio rerio (zebrafish) ]

Gene ID: 393289, updated on 27-Mar-2024

Summary

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Official Symbol
maco1aprovided by ZNC
Official Full Name
macoilin 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1097
See related
Ensembl:ENSDARG00000005625 AllianceGenome:ZFIN:ZDB-GENE-040426-1097
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tmem57; tmem57a; zgc:56620; macoilin-1
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in chemotaxis and neuronal signal transduction. Predicted to be located in endoplasmic reticulum; membrane; and nucleus. Predicted to be integral component of membrane. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See maco1a in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (29303847..29333867)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (29716624..29746644)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene serum response factor binding protein 1 Neighboring gene low density lipoprotein receptor adaptor protein 1a Neighboring gene fibronectin type III domain containing 5b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure. Li X, et al. Gene, 2015 Oct 10. PMID 26072164
  2. Evolutionary and Expression Analyses Show Co-option of khdrbs Genes for Origin of Vertebrate Brain. Wang S, et al. Front Genet, 2017. PMID 29354154, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56620

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuronal signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in rough endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
macoilin-1
Names
transmembrane protein 57
transmembrane protein 57a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200319.2 → NP_956613.2  macoilin-1

    See identical proteins and their annotated locations for NP_956613.2

    Status: PROVISIONAL

    Source sequence(s)
    AY845029
    UniProtKB/Swiss-Prot
    Q1L869, Q2TLY0, Q2TLY2
    Related
    ENSDARP00000008156.8, ENSDART00000009149.9
    Conserved Domains (3) summary
    pfam09726
    Location:2 → 662
    Macoilin; Transmembrane protein
    pfam13493
    Location:31 → 114
    DUF4118; Domain of unknown function (DUF4118)
    pfam16331
    Location:386 → 462
    TolA_bind_tri; TolA binding protein trimerization

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    29303847..29333867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TLY2.1 GenPept UniProtKB/Swiss-Prot:Q2TLY2

Gene LinkOut

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