cyp46a1.4 cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp46a1.4provided by ZNC
Official Full Name: cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1224
See related: Ensembl:ENSDARG00000113820 AllianceGenome:ZFIN:ZDB-GENE-040426-1224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp46a2; zgc:63667
Summary: Predicted to enable cholesterol 24-hydroxylase activity and heme binding activity. Predicted to be involved in cholesterol catabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (5256129..5268593, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (5211744..5224212, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol 24-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol 24-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 46A1.4; cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4

Names: cyp46a4; cytochrome P450, family 46, subfamily A, polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200479.2 → NP_956773.1 cytochrome P450 46A1.4

See identical proteins and their annotated locations for NP_956773.1

Status: PROVISIONAL

Source sequence(s)

BC055195

UniProtKB/TrEMBL

Q7SXY7

Related

ENSDARP00000090030.5, ENSDART00000099258.5

Conserved Domains (1) summary

pfam00067
Location:8 → 438

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

5256129..5268593 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160347.4 → XP_005160404.1 cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4 isoform X1

UniProtKB/TrEMBL

A0A8M2B763

Conserved Domains (1) summary

pfam00067
Location:39 → 495

p450; Cytochrome P450