aldh2.1 aldehyde dehydrogenase 2 family member, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aldh2.1provided by ZNC
Official Full Name: aldehyde dehydrogenase 2 family member, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1262
See related: Ensembl:ENSDARG00000089924 AllianceGenome:ZFIN:ZDB-GENE-040426-1262
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: aldh2; aldh2a; zgc:63786
Summary: Enables 3-chloroallyl aldehyde dehydrogenase activity. Predicted to act upstream of or within cellular aldehyde metabolic process. Is expressed in several structures, including fin; heart; liver; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (69574673..69595487, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (68802121..68822935, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism.
Title: Accumulation of acetaldehyde in aldh2.1(-/-) zebrafish causes increased retinal angiogenesis and impaired glucose metabolism.

Submit: New GeneRIF Correction

General gene information

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Markers

fi26c02.x1 (e-PCR)
- UniSTS:197121

fb43g02.x1 (e-PCR)
- UniSTS:190578

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular aldehyde metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aldehyde dehydrogenase 2 family member, tandem duplicate 1

Names: aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1; aldehyde dehydrogenase 2 family (mitochondrial)a; aldehyde dehydrogenase 2, tandem duplicate 1; aldehyde dehydrogenase 2.1

NP_956784.1

EC 1.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200490.1 → NP_956784.1 aldehyde dehydrogenase 2 family member, tandem duplicate 1

See identical proteins and their annotated locations for NP_956784.1

Status: PROVISIONAL

Source sequence(s)

BC055244

UniProtKB/TrEMBL

Q7SXU3

Related

ENSDARP00000012767.8, ENSDART00000016808.9

Conserved Domains (1) summary

cd07141
Location:30 → 510

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like