cyp2k6 cytochrome P450, family 2, subfamily K, polypeptide 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp2k6provided by ZNC
Official Full Name: cytochrome P450, family 2, subfamily K, polypeptide 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1571
See related: Ensembl:ENSDARG00000098995 AllianceGenome:ZFIN:ZDB-GENE-040426-1571
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66225
Summary: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Acts upstream of or within aflatoxin metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver and ovary. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (12816335..12826517)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (12664913..12674946)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cloning of CYP2K6 from adult zebrafish; recombinant protein was shown to activate aflatoxin B1 to an exo-8,9-epoxide metabolite
Title: CYP2K6 from zebrafish (Danio rerio): cloning, mapping, developmental/tissue expression, and aflatoxin B1 activation by baculovirus expressed enzyme.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dibenzothiophene-5,5-dioxide monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables pyrrole-2-carboxylate monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aflatoxin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 2K6; cytochrome P450, family 2, subfamily K, polypeptide 6

XP_009297487.1

EC 1.14.14.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200509.2 → NP_956803.2 cytochrome P450 2K6

Status: VALIDATED

Source sequence(s)

AL929078, BX511176

UniProtKB/Swiss-Prot

F1Q8C3, Q7SXK7, Q802U6, Q90Y45

Related

ENSDARP00000134138.1, ENSDART00000163743.2

Conserved Domains (1) summary

pfam00067
Location:64 → 500

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

12816335..12826517

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009299212.3 → XP_009297487.1 cytochrome P450, family 2, subfamily K, polypeptide 6 isoform X1

UniProtKB/Swiss-Prot

F1Q8C3

Related

ENSDARP00000135007.1, ENSDART00000170788.2

Conserved Domains (1) summary

pfam00067
Location:64 → 500

p450; Cytochrome P450