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gid8a GID complex subunit 8 homolog a (S. cerevisiae) [ Danio rerio (zebrafish) ]

Gene ID: 393685, updated on 27-Mar-2024

Summary

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Official Symbol
gid8aprovided by ZNC
Official Full Name
GID complex subunit 8 homolog a (S. cerevisiae)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1669
See related
Ensembl:ENSDARG00000022768 AllianceGenome:ZFIN:ZDB-GENE-040426-1669
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Twa1; gid8; zgc:73100
Summary
Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within determination of dorsal identity. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See gid8a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23147258..23151984)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23126019..23130745)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene microRNA 124-6 Neighboring gene si:ch211-196c10.13 Neighboring gene solute carrier family 17 member 9a Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 5aa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Lu Y, et al. Cell Res, 2017 Dec. PMID 28829046, Free PMC Article
  2. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC73100

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glucose-induced degradation protein 8-A homolog; glucose-induced degradation protein 8 homolog
Names
protein C20orf11 homolog
two hybrid-associated protein 1 with RanBPM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200712.1 → NP_957006.1  glucose-induced degradation protein 8-A homolog

    See identical proteins and their annotated locations for NP_957006.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059468
    UniProtKB/Swiss-Prot
    Q6PC55
    Related
    ENSDARP00000035630.4, ENSDART00000030920.6
    Conserved Domains (4) summary
    smart00668
    Location:63 → 119
    CTLH; C-terminal to LisH motif
    smart00757
    Location:116 → 212
    CRA; CT11-RanBPM
    pfam08513
    Location:28 → 53
    LisH; LisH
    pfam10607
    Location:63 → 207
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    23147258..23151984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357294.2 → XP_017212783.1  glucose-induced degradation protein 8 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q6PC55
    Related
    ENSDARP00000145022.1, ENSDART00000180284.1
    Conserved Domains (4) summary
    smart00668
    Location:63 → 119
    CTLH; C-terminal to LisH motif
    smart00757
    Location:116 → 212
    CRA; CT11-RanBPM
    pfam08513
    Location:28 → 53
    LisH; LisH
    pfam10607
    Location:63 → 207
    CLTH; CTLH/CRA C-terminal to LisH motif domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PC55.1 GenPept UniProtKB/Swiss-Prot:Q6PC55

Gene LinkOut

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