pcmtl l-isoaspartyl protein carboxyl methyltransferase, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcmtlprovided by ZNC
Official Full Name: l-isoaspartyl protein carboxyl methyltransferase, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1738
See related: Ensembl:ENSDARG00000042848 AllianceGenome:ZFIN:ZDB-GENE-040426-1738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73268
Summary: Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to act upstream of or within cellular protein modification process and methylation. Predicted to be active in cytoplasm. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (31214190..31221666, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (31197227..31204720, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: l-isoaspartyl protein carboxyl methyltransferase, like

XP_005158823.1

EC 2.1.1.77

XP_005158824.1

EC 2.1.1.77

XP_009291400.1

EC 2.1.1.77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200768.2 → NP_957062.2 l-isoaspartyl protein carboxyl methyltransferase, like precursor

Status: VALIDATED

Source sequence(s)

BX649281

Related

ENSDARP00000118411.1, ENSDART00000132858.3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

31214190..31221666 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158767.4 → XP_005158824.1 l-isoaspartyl protein carboxyl methyltransferase, like isoform X1

See identical proteins and their annotated locations for XP_005158824.1

UniProtKB/TrEMBL

A0A8M2B570

Related

ENSDARP00000154840.1, ENSDART00000180485.1

Conserved Domains (2) summary

pfam01135
Location:30 → 237

PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

cl17173
Location:34 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_005158766.4 → XP_005158823.1 l-isoaspartyl protein carboxyl methyltransferase, like isoform X1

See identical proteins and their annotated locations for XP_005158823.1

UniProtKB/TrEMBL

A0A8M2B570

Conserved Domains (2) summary

pfam01135
Location:30 → 237

PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

cl17173
Location:34 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_009293125.3 → XP_009291400.1 l-isoaspartyl protein carboxyl methyltransferase, like isoform X2

UniProtKB/TrEMBL

A0A8M3AJ35, F1QL05

Related

ENSDARP00000112514.1, ENSDART00000145010.3

Conserved Domains (2) summary

pfam01135
Location:30 → 237

PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

cl17173
Location:34 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...